Experimental design 342 INDEX

Statistical analysis using spreadsheet format experimental design. Index of available macros and other statistical information can be obtained by sending the message send index to statlib lib.stat.cmu.edu. PCs (DOS and Windows), Macintosh, VAX, and mainframes. 

Kalogerakis, N., and R. Luus, "Sequential Experimental Design of Dynamic Systems Through the Use of Information Index", Can. J. Chem. Eng., 62, 730-737(1984). 

Experimental design The authors investigated the ability of chloroform vapors to produce toxicity and regenerative cell proliferation in female B6C3Fj mice and male Fischer 344 rats. Groups of 5 animals were exposed to 0, 1,3, 10, 30, 100, or 300 ppm chloroform via inhalation for 6 hours a day for 7 consecutive days. Actual exposure concentrations measured for mice were 0, 1.2, 3.0, 10.0, 29.5, 101, and 288 ppm and for rats were 0, 1.5, 3.1, 10.4, 29.3, 100, and 271 ppm. Necropsies were performed on day 8. Animals were administered bromodeoxyuridine (BrdU) via implanted osmotic pump for the last 3.5 days. Cell proliferation was quantitated as the percentage of cells in S-phase (labeling index = LI) measured by the immunohistochemical detection of BrdU-labeled nuclei. 

We seek to determine an optimal composition of a multicomponent solvent utilized to remove hydrocarbons from yeast. The major index of purification here is the hydrocarbon content in biomass upon extraction (y). For technological and economic reasons, the experimental design is accomplished in a local section of the concentration, Fig. 3.23. 

Index Entries Monolaurin immobilized lipase esterification experimental design solvent-free medium. 

Index Entries Nisin whey fermentation optimization experimental design. 

Response Surfaces. 3. Basic Statistics. 4. One Experiment. 5. Two Experiments. 6. Hypothesis Testing. 7. The Variance-Covariance Matrix. 8. Three Experiments. 9. Analysis of Variance (ANOVA) for Linear Models. 10. A Ten-Experiment Example. 11. Approximating a Region of a Multifactor Response Surface. 12. Additional Multifactor Concepts and Experimental Designs. Append- ices Matrix Algebra. Critical Values of t. Critical Values of F, a = 0.05. Index. 

Experimental design. This MRL is based on the results of the Seychelles Child Development Study (SCDS), a series of evaluations on a population in the Seychelles Islands. The chronic oral MRL for methylmercury is based upon the Seychelles Child Development Study (SCDS), in which over 700 mother-infant pairs have, to date, been followed and tested from parturition through 66 months of age (Davidson et al. 1998). The SCDS was conducted as a double-blind study and used maternal hair mercury as the index of fetal exposure. Enrollees were recruited by the head nurse/hospital midwife by asking the mothers if they wished to participate in the study when they arrived at the hospital for delivery. The first 779 who did not decline participation became the mothers in the study cohort. Of the initial 779 mothers enrolled in the study at parturition, 740 remained at the predetermined child testing age of 6.5 months,... 

In a simplified representation, Knowles and co-workers (101) have suggested use of the Quality Index, Q, as a measure of the quality of both the experimental design and its execution. Assuming the I80 enrichment in the l80-position is very close to 100%, the maximum ratio of peak intensities b/c in Fig. 2B (and c/b in Fig. 2C) is 1/x, where x = fractional 160 and 18O contents of the 170 used. They define Qmax as 1-x, the fractional 170 content of the 170 used. The experimental results provide Qobs, which is the fractional difference... 

The above relationship shows the possibility of estimating the equilibrium concentration Cg on the basis of experimentally designated values Am, S and the refractive index profile n(x) of produced waveguide. 

It is remarkable that only two descriptors were needed in this method. However, this equation is mostly only of historical interest as it is of little use in modem dmg and combinatorial library design because it requires a knowledge of the compound s experimental melting point which is not available for virtual compounds. Several methods exist for estimating log P [1-14], but only a few inroads have been made into the estimation of melting points. The melting point is a key index of the cohesive interactions in the solid and is still difficult to estimate. 

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