Evolutionary relatedness

Proteins have unique amino acid sequences, and it is this uniqueness of sequence that ultimately gives each protein its own particular personality. Because the number of possible amino acid sequences in a protein is astronomically large, the probability that two proteins will, by chance, have similar amino acid sequences is negligible. Consequently, sequence similarities between proteins imply evolutionary relatedness. 

Multiple alignment Multiple sequence alignment involves the simultaneous comparison of several distinct sequences. If these sequences represent a single protein across multiple species, the alignment will indicate evolutionary relatedness. Alternatively, alignment of proteins within a single... 

Any host system different from CHO will be subject to the same regulatory scrutiny. For obvious reasons, due to the evolutionary relatedness of all mammalian species, regulatory concerns for the transmission of unknown disease-causing principles is higher when utilizing a hamster-... 

The NAD(P) -dependent dehydrogenases constitute the single most extensively studied class of enzymes with respect to reaction stereochemistry. In the most recent compilation of 157 dehydrogenases, 77 are A-side specific and 80 are B-side specific 34) examples are given in Table 1. Whether the observed stereochemistries of the dehydrogenases have a basis in mechanism or evolutionary relatedness is currently a matter of debate (2). 

To determine the evolutionary relatedness of strains, use the Cluster program (11) based on the presence or absence of all open reading frames (ORFs) represented on the microarray. 

The concept of Evolution was first developed by Lamarck in early 1 9th century. It was suggested that similar taxa were so, not because they performed similar roles in nature, but because they shared a common ancestry in a recent past. This idea of progressive transformations, initially very controversial, became prevalent among biologists, espreially after Darwin proposed that natural selection was the main cause of the evolutional process. Taxonomists became involved, not only in the description of species, but also in the establishment of the evolutionary relatedness between taxa, i.e. their phytogeny. 

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