European Union Reference

At tbe time that the U. K. and European Union reference intakes of folate shown in Table 10.3 were being discussed, the results of intervention trials for the prevention of neural tube defects (Section 10.9.4) were only just becoming available. At that time, there was no information concerning the effects of folate status onhyperhomocysteinemia (Section 10.3.4.2). TheU.S./Canadianreport (Institute of Medicine, 1998) notes specifically that protective effects with respect to neural tube defects were not considered relevant to the determination of the Dietary Reference Intake of folate, and there was insufficient evidence to associate higher intakes of folate (and lower plasma concentrations of homocysteine) with reduced risk of cardiovascular disease. 

European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM), Systems Toxicology Unit institute for Health and Consumer Protection,... 

Anna Bal-Price European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM), Systems Toxicology Unit, Institute for Health and Consumer Protection, Joint Research Centre, European Commission, Ispra (VA), Italy David Basketter DABMEB Consultancy Ltd, Bedfordshire, UK Camilla Bernasconi European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM), Systems Toxicology Unit, Institute for Health and Consumer Protection, Joint Research Centre, European Commission, Ispra, VA, Italy Bas J. Blaauboer Division of Toxicology, Institute for Risk Assessment Sciences,... 

Siegfried Morath European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM), Systems Toxicology Unit, Institute for Health and Consumer Protection, Joint Research Centre, European Commission, Ispra, VA, Italy Olavi Pelkonen Department of Pharmacology and Toxicology, University of Oulu,... 

European Union Reference Laboratory for Crustacean Diseases Cefas Weymouth Laboratory is the designated European Union Reference Laboratory (EURL) for Crustacean Diseases. http //www.crustaceancrl. eu/... 

Reference laboratories are important resources within animal disease diagnosis. These are internationally recognised facilities that have a combination of skilled personnel, validated diagnostic tests, reagents and appropriate archive material. The European Union Reference Laboratory (EURL-FISH) is funded by the EU Commission and is located in the national veterinary institute, Aarhus, Denmark. The main purpose of the EURL is to ensure high quality of all fish diagnostics performed in the member states of the EU. Furthermore this aids in the harmonisation of the protocols and methodologies applied for the various fish diseases, as described in Council Directive 2006/88/EC. The EURL is primarily concerned with notifiable viral diseases of fish (www.crl-fish.eu). 

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