Ethylamino acetate

Ethylamino acetate CH3C(0)0NHCH2CH3 95.4 399.2 Correlation 2005DEN/TUM... 

Sufficient activation was present in 5-ethylamino-2-oxoimidazolo [4,5-6]pyrazine (173) for it to be halogenated in the 6-position by chlorine and bromine in acetic acid or by sulfuryl chloride (69FRP1578366 71BRP1248146). The 2-oxo group could be replaced by chlorine (75KFZ10 76KFZ35). 

Preparation of 2 -Anilino-6 - [N- (3-bromopropyl) -N-ethylaminoJ-3 -methylfluoran (89). To a mixture of 2 -anilino-6 -[/V-ethyl-Af-( 3-methoxy-propyl)amino]-3 -methylfluoran (0.1 mol) and 48% hydrobromic acid (150 ml) was added dropwise concentrated sulfuric acid (20 ml) with vigorous stirring. Then, the resulting mixture was stirred at 110-115 °C for 1 h, poured into ice water (1000ml), and made alkaline by aqueous sodium hydroxide. The pale violet precipitate was filtered off, and recrystallized from ethyl acetate-isopropanol to give 2 -anilino-6 -[/V-(3-bromopropyl)-,V-ethylamino]-3 -methylfluoran in 96% yield, mp 160-162 °C. 

There is a roughly inverse relationship for a series of structurally related dyes between the time of half-dyeing and the saturation solubility in an appropriate substrate, as illustrated for several 4-alkylamino derivatives of 1-anilinoanthraquinone on cellulose acetate (Table 3.17). It is interesting that methylamino and 2-hydroxyethylamino substituents confer good solubility in this substrate, but ethylamino groups are even less effective than isobutylamino groups in this respect [114]. 

The heating of [2-(3,4-dimethoxyphenyl)ethylamino]methylenemal-onates (1386) in 24% aqueous hydrochloric acid gave tetrahydroisoquino-line-l-acetic acid hydrochlorides (1387) in good yields (56JOC336 761JC784). 

Chemicals processed. Waste pesticide solutions were collected after spray operations during late May, June, and July of 1983, and consisted primarily of three compounds 2,4-D [(2,4-dichloro-phenoxy)acetic acid], atrazine (2-chloro-4-(ethylamino)-6-(isopropylamino)- -triazine) and paraquat (1,1 -dimethyl-4,4 -bipyridinium dichloride). Our efforts were primarily directed at these pesticides, which are shown in Table I together with their formulations and concentrations. 

Introduction of the C2 sulfonamide is accomplished via sulfonylation with chlorosulfonic acid, conversion to the sulfonyl chloride using thionyl chloride, and amidation using concentrated ammonium hydroxide in tetrahydrofuran. Reduction of the 4-acetamido compound using borane-tetrahydrofuran complex provides the 4-ethylamino derivative. The 45,65-frans diastereomer is selectively crystallized as its maleate salt from acetone in the presence of the unwanted 4R,6S-cis diastereomer. Neutralization of the maleate salt and extraction of the free base in ethyl acetate, followed by formation of the hydrochloride salt, yields crude dorzolamide hydrochloride. 

Examples of this ring system (263) were prepared by cyclocondensation of anthranilic acid with the 1,3-thiazole derivatives 262 (82MI1 83AP394). Reductive cyclization of the 4-ethylamino-3-(2-nitrobenzyl)thiazolidines (264) was affected by heating with iron filings and acetic acid to give 4//-3,3a-dihydrothiazolo[4,3- >]quinazoline (265) (87JHC107). 

DicyarL-methylen)-l,3-oxazolidin reagiert mit Hydrazin-Hydrat als cyclisches Keten-N,0-acetal zu 3(5)-Amino-4-cyan-5(3)-(2-hydroxy-ethylamino)-l H-pyrazol (39% Schmp. ... 

Chlorophenyl)-,V-[4-(diethylamino)-l-methylbutyl]pyrido[3,4-/)]pyrazin-5-amine (5a) reacts with bromine in acetic acid solution to give a 43% yield of 8-bromo-2-(2-chlorophenyl)-Af-[4-(di-ethylamino)- -methylbuty]]pyrido[3,4-/ ]pyrazin-5-amine (6a) similarly 2-chloro-JV-[4-(diethyl-amino)-l-methylbutyl]pyrido[3,4-6]pyrazin-5-amine (5b) affords the corresponding 8-bromo compound 6b.116... 

Oxeladlll. a,a -Diethylbemeneacetic acid 2-[2-(di-ethylamino ethoxy]ethyl ester 2-ethyl-2-phenylbutyric acid 2-(2-diethylaminoetho.xy)ethyl ester 2-(2-diethylaminoeth-oxy)ethyl a,o-diethy]phenylacetate a.a -dieth y 1 phenyl acetic acid 2-(2-diethylaminoethoxy)ethyl ester. C H NO, mol wt 335.47. C 71.60%. H 9.92%, N 4.18%, O 14.31%. Prepn V. Petrow et al, J. Pharm. Pharmacol. 10, 40 (1958) eidem. U.S. pat. 2,885,404 (1959 to Brit. Drug Houses). 

Esterification of tropic acid with acetyl chloride gives tropic acid acetate which on chlorination with thionyl chloride yields the corresponding acid chloride. The resulting product on treatment with 4-((ethylamino) methyl-pyridine and subsequently with an appropriate dehydrochlorinating agent gives rise to tropicamide acetate. Saponification of this compound affords the desired official product. 

A mixture of 2-ethylamino-5-nitro-4-thiocyanatopyrimidine, Fe-powder, and acetic acid stirred 2 hrs. at 60° -> crude 2-amino-5-ethylaminothiazolo[5,4-d]pyrimidine. Y ca. 100. F. e. s. S. Sugiura et al., Chem. Pharm. Bull. 16, 745 (1968). 

Ethenediyl) bis(5-(4-(ethylamino)-6-(phenylamino)-1,3,5-triazin-2-yl) amino) benzenesulfonic acid, disodium salt. See Disodium bisethylphenyl triaminotriazine stilbenedisulfonate Ethene, homopolymer. See Polyethylene Ethene, homopolymer, oxidized. See Polyethylene, oxidized Ethene oxide. See Ethylene oxide Ethene polymer. See Polyethylene Ethenol homopolymer. See Polyvinyl alcohol Ethenyl acetate, homopolymer. See Polyvinyl acetate Ethenylbenzenesulfonic acid, sodium salt, homopolymer 4-Ethenylbenzene-sulfonic acid sodium salt, homopolymer. See Sodium polystyrene sulfonate 1-Ethenyl-2-pyrrolidinone. See N-Vinyl-2-pyrrolidone l-Ethenyl-2-pyrrolidinone homopolymer. See PVP... 

Sterols, soybean. See Soybean (Glycine soja) sterol Soy sterol Sterols, soybean, acetates. See Soy sterol acetate 2,2 -Stilbenedisulfonic acid, 4,4 -bis ((4-anilino-6-ethylamino-s-triazin-2-yl) amino)-, disodium saK. See Disodium bisethylphenyl triaminotriazine stil-benedisulfonate... 

Nakagawa et al. (275) believe that when photosensitized oxidations of tryptophan are carried out in solvents such as formic acid, acetic acid and water, participation of the ethylamino side chain is unfavorable and that the reaction consequently proceeds via the alternative path A of pyrrole ring cleavage. However, Savige (339) recently found that photooxidation of tryptophan in water, in the presence of methylene blue... 

---