Ethyl benzylamine

Guoiacol (2-methoxy- phenoi) 1,2-dibrofTio-ethane N-[2-(2-methoxyphen oxy)ethyl]benzylamine... 

The mixed-donor tridentate ligands bis[2-diphenylphosphino)ethyl] benzylamine (dpba) and bis[2-(diphenylarsino)ethyl] benzylamine (daba) form square-planar complexes with IrCl and IrPPh3 moieties.664... 

On treatment with a Cu(I) complex of A(,A(-bis[2-(iV-methylbenzimidazol-2-yl)ethyl]benzylamine in MeCN followed by exposure to O2, the sodium salt of 4-carbethoxy-2,6-di(terr-butyl)phenol (226) was selectively oxidized to afford in ca 80% yield 4-carbethoxy-3,6-di(terr-butyl)-o-benzoquinone (227), which is probably produced from the Cu(l) peroxide 228 by a 1,2-migration of a teri-butyl group (Scheme 45) °. 

Synonyaa a-Methylbenaenemethanamine a-phenylethylamine a- ethyl-benzylamine 1-phenylethylamine cx-aminoethylbenzene Ttade names ... 

I. Mixed solvents - water/MEK, water/2-pentanone, water/other higher ketones, water/ethylene glycol methyl butyl ether, water/propylene glycol propyl ether, glycerol/guaiacol, glycerol/m-toluidine, glycerol/ethyl benzylamine, water/pyridines, water/piperidines (International Critical Tables, Volume 111, 1928, pp. 386-398 Seidell and Linke, 1952)... 

In general the method is more satisfactory with esters of aromatic acids than with esters of aliphatic acids. Esters of alcohols other than methyl and ethyl are best treated by first converting them into methyl esters thus Heat together under reflux i ml. of the higher ester, 5 ml. of methanol and 0-2 g. of sodium methoxide. [In place of the sodium methoxide, it suffices to add o i g. of metallic sodium to the methanol.] After refluxing, distil off the excess of methanol (b.p, 65 ). The residue is then heated under reflux with benzylamine as described above. 

The reaction (which is essentially the direct aminolysis of esters with benzylamine) proceeds readily when R is methyl or ethyl. Esters of higher alcohols should preferably be subjected to a preliminary methano-lysis by treatment with sodium methoxide in methanol ... 

The respective amide was prepared from 7-substituted 5-oxo-2,3-dihydro-5//-pyrido[l,2,3-de]-l,4-benzoxazine-6-carboxylic acids via acid chlorides with different benzylamines (00M1P3). 6-Carboxamides were N-benzylated, and a side-chain phenolic hydroxy group was O-alkylated. 7-Aryl-5-oxo-2,3-dihydro-5//-pyrido[l, 2,3-r/e]-1,4-benzoxazine-6-carboxylic acid was obtained from the ethyl ester by alkalic hydrolysis. 

The majority of analgesics can be classified as either central or peripheral on the basis of their mode of action. Structural characteristics usually follow the same divisions the former show some relation to the opioids while the latter can be recognized as NSAlD s. The triamino pyridine 17 is an analgesic which does not seem to belong stmcturally to either class. Reaction of substituted pyridine 13 (obtainable from 12 by nitration ) with benzylamine 14 leads to the product from replacement of the methoxyl group (15). The reaction probably proceeds by the addition elimination sequence characteristic of heterocyclic nucleophilic displacements. Reduction of the nitro group with Raney nickel gives triamine 16. Acylation of the product with ethyl chlorofor-mate produces flupirtine (17) [4]. 

A slurry of 1 S> g (0.034 mol) of 1-isonicotinvl-2-(carbomethoxvethyl)-hvdrazine and 5 ml of benzylamine is heated with stirring at 130 C for three hours. The cooled mass is then recrys-tallized from ethyl acetate to yield white needles melting at 151.1°C to 152.1°C. 

Relative rates of alkylation of toluene and benzene using a mixture of nitro-sonium hexafluorophosphate, nitromethane (or acetonitrile) and aliphatic amine as the alkylations agent have been determined at 25 °C as follows360 1.5 (ethyl-amine), 2.5 (i-propylamine) and 3.5 (benzylamine) nothing more as yet is known about the kinetics of alkylation with these new alkylating reagents. 

Fenton and co-workers observed the hydrolysis of bis- and tris-nitrophenyl phosphate with the zinc complex of the pentadentate N302 ligand V,V - (salicylideneimino)-ethyl -2-hydroxy-5-nitro-benzylamine.890... 

The reaction of racemic Sb-chiral l-phenyl-2-trimethylsilylstibindole with the optically active ortho-palladated benzylamine derivative, di-p-chlorobis (S)-2-[l-dimethylamino)ethyl]phenyl-C,N dipalladium, leads to diastereomeric complexes which were used for the separation of the enantiomers of the stibindoles.65 The molecular structures of the diastereomeric palladium complexes are depicted in Fig. 4. 

TABLE 10. The secondary alpha deuterium and secondary incoming nucleophile deuterium kinetic isotope effects found for the S 2 reactions between para-substituted anilines and benzylamines with benzyl, methyl and ethyl para-substituted benzensulfonates in ace- ... 

When the decomposition of the zwitterionic intermediate is rate-determining, the effect of the solvent is crucial since it may produce changes in the mechanisms and in the rate-determining step. A recent study of the kinetics of the reactions of 1-chloro-, 1-fluoro- and l-phenoxy-2,4-dinitrobenzene with piperidine, n-butylamine and benzylamine in ethyl acetate and THF indicated that these reactions resemble those in dipolar aprotic solvents when primary amines are the nucleophiles (i.e. that shown in equation 1, with... 

Kinetic studies of the reaction of Z-phenyl cyclopropanecarboxylates (1) with X-benzylamines (2) in acetonitrile at 55 °C have been carried out. The reaction proceeds by a stepwise mechanism in which the rate-determining step is the breakdown of the zwitterionic tetrahedral intermediate, T, with a hydrogen-bonded four-centre type transition state (3). The results of studies of the aminolysis reactions of ethyl Z-phenyl carbonates (4) with benzylamines (2) in acetonitrile at 25 °C were consistent with a four- (5) and a six-centred transition state (6) for the uncatalysed and catalysed path, respectively. The neutral hydrolysis of p-nitrophenyl trifluoroacetate in acetonitrile solvent has been studied by varying the molarities of water from 1.0 to 5.0 at 25 °C. The reaction was found to be third order in water. The kinetic solvent isotope effect was (A h2o/ D2o) = 2.90 0.12. Proton inventories at each molarity of water studied were consistent with an eight-membered cyclic transition state (7) model. 

The starting l-benzylpiperidin-4-one (3.1.48) is synthesized by Dieckmann intermolec-ular condensation of iV-benzyl-iV,iV-fct)y-(j3-carboethoxyethyl)amine (3.1.46), which is easily formed by reaction of benzylamine with ethyl acrylate to give l-benzyl-3-carboethoxy-piperidine-4-one (3.1.47) followed by acidic hydrolysis and thermal decarboxylation. 

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