Ethyl acetate benzoate

Ethyl benzoate Ethyl acetate Ethyl benzoylacetate. 

As a general guide, however, it may be noted that the following have fairly easily recognisable odours methyl and ethyl formate methyl and ethyl acetate (apples) methyl and ethyl benzoate methyl salicylate (oil of winter-green) and ethyl salicylate methyl and ethyl cinnamate. (It is however usually impracticable to distinguish by odour alone between the methyl and ethyl esters of a particular acid.) Methyl and ethyl o. alate, and methyl and ethyl phthalate are almost odourless. Succinic and tartaric esters have faint odours. 

Ester formation. Add carefully 1 ml. of the liquid to i ml. of ethanol and then warm gently for i minute. Pour into water, make alkaline with aqueous Na2C03 solution (to remove HCl and other acid fumes), and note the odour of ethyl acetate or ethyl benzoate. 

Esters. re-Butyl acetate Ethyl acetate Ethyl benzoate. 

Standnikow has prepared several of the esters of menthol by heating magnesium iodo-mentholate with the esters of ethyl alcohol. For example, with ethyl acetate, propionate, and benzoate the corresponding menthyl esters were obtained. These bodies have the following boiling-points —... 

Ethyl benzoylacetate has been prepared by the condensation (by means of sodium ethylate) of ethyl acetate with ethyl benzoate,1 acetophenone with ethyl carbonate,2 and acetophenone with ethyl oxalate, with subsequent heating 3 by treatment of ethyl phenylpropiolate4 or a-bromocinnamic acid 5 with concentrated sulfuric acid, and of ethyl diazoacetate with benzalde-hyde 6 by the condensation of benzene with the monoethyl ester of malonyl monoacid chloride and aluminum chloride,7 of benzoyl chloride with the product of the reaction of magnesium and ethyl chloroacetate in ether,8 of alcohol on benzoylacetimino ethyl... 

The initial study of the La3 +-catalyzed methanolysis of carboxylate esters163 reported the apparent second-order rate constant for La2 + ( OCH3)2-catalyzed methanolysis of some representative examples of aryl esters (2, 5 and 2,4-dinitrophenyl acetate (14)), phenyl benzoate (15) and three aliphatic esters, ethyl acetate, isopropyl acetate (16) and tert-butyl acetate (17). Given in Table 6 are the rate constants for the La3+ and methoxide-catalyzed methanolysis of these esters along with... 

Benzoylacetone. — C6H5.CO.CH2.CO.CH3 is prepared in an analogous way from acetophenone and ethyl acetate according to the procedure of Claisen, Ber., 1905, 38, 695. The yield may be as much as 75 per cent of the theoretical. The cheaper converse method—action of sodamide on ethyl benzoate and acetone—also succeeds in this case, although it fails when sodium or sodium ethoxide is used as condensing agent. In general the use of sodamide is to be preferred in the synthesis of 1 3-diketones. 

Conversion data listed in Table 2 indicate that in the hydrogenation of 4-amino-ethyl benzoate using cyclohexane as a solvent the AI2O3 supported Ru and Rh catalysts are more active than the carbon supported ones. In addition, the conversion of aromatic ester is smaller on Pd/C catalyst than on the carbon supported Ru and Rh. In ethyl acetate the hydrogenation proceeded slower than in cyclohexane, and Rh being more active than Ru. The trans/cis isomer ratio estimated from TLC results varied between 1/3 and 1/1. The UV active by-products were formed in coupling reactions. 

Nitroform, Methanol, Hydrazine Nitroform, Diethyl ether, Hydrazine Nitroform, Methyl acetate, SUver-I oxide, 1,4-Dibromobutyne-2, Chloroform Glyoxal, Benzylamine, Formic acid, Acetonitrile, Acetic anhydride. Palladium on charcoal, Bromobenzene, Chloroform, Sulfolane, Nitrosonium tetrafluoroborate. Ethyl acetate TNT, DMSO, Oxygen gas. Sodium benzoate. Hydrochloric acid. Methanol, Acetone... 

Esters show similar behaviour. Hantzsch found the /-factor for ethyl acetate to be close to 2, and accurate determinations by Leisten also gave values close to 2 for ethyl and methyl benzoate and p-nitrobenzoate. In a solvent containing sufficient water, hydrolysis of the ester occurs. The reaction of methyl benzoate has a time of half-change of a few hours at 25°C in sulphuric acid containing about 0.07 M water, and Leisten actually used the increase in the / -factor, from 2 to 3, to follow the hydrolysis reaction, viz. 

Ethyl acetate Methyl propanoate 2-Chloroethyl benzoate... 

Cyclonite is a white crystalline solid, m.p. 202°. It is insoluble in water, alcohol, ether, ethyl acetate, petroleum ether, and carbon tetrachloride, very slightly soluble in hot benzene, and soluble 1 part in about 135 parts of boiling xylene. It is readily soluble in hot aniline, phenol, ethyl benzoate, and nitrobenzene, from all of which it crystallizes in needles. It is moderately soluble in hot acetone, about 1 part in 8, and is conveniently recrystallized from this solvent from which it is deposited in beautiful, transparent, sparkling prisms. It dissolves very slowly in cold concentrated sulfuric acid, and the solution decomposes on standing. It dissolves readily in warm nitric acid (1.42 or stronger) and separates only partially again when the liquid is cooled. The chemical reactions of cyclonite indicate that the cyclotrimethylenetri-nitramine formula which Herz suggested for it is probably correct. 

The enolate of ethyl acetate behaves as a nucleophile and the nonenolizable ester, ethyl benzoate, behaves as an electrophile. 

Acetic acid (0.2 g) was added to a solution of ethyl-3-amino-2-[[(2 -cyanobiphenyl-4-yl)methyl]amino]benzoate (1 g) in ethylorthocarbonate (5 ml). The mixture was stirred at 80°C for 1 hours. The reaction mixture was concentrated. The solution was washed with an aqueous solution of NaHC03 and water. The solvent was evaporeted to give crystals. Recrystallization from ethyl acetate-benzene afforded colorless crystals l-[(2 -cyanobiphenyl-4-yl)methyl]-2-ethoxybenzimidazole-7-carboxylate (0.79 g, 69%), M.P. 131-132°C. 

To a solution of 20 g of (-)-3a,5a-dihydroxy-2p-(hydroxymethyl)cyclopentane-la-acetic acid y-lactone 3-benzoate in 320 ml of methylene chloride under nitrogen atmosphere and cooled in an ice bath was added dropwise 24.8 ml of boron trifluoride in 320 ml of methylene chloride. After 1 hour to the solution was added 78 g of sodium carbonate in 200 ml of water and then 66 g of solid sodium chloride. The aqueous phase was extracted with ethyl acetate. Yield of (-)-3a,5a-dihydroxy-2p-(methoxymethyl)cyclopentane-la-acetic acid... 

To a solution of 0.50 g of (-)-3a,5a-dihydroxy-2p-[(3RS)-3-hydroxy-3-methyl-trans-octenyl]cyclopentane-la-acetic acid - lactone 3-benzoate in 15 ml of tetrahydrofuran at -78°C under nitrogen was added 10 ml of 10% diisobutylaluminum hydride in toluene. After a gas evolution was ceased, the reaction was quenched by addition of 10 ml of saturated aqueous ammonium chloride. The resulting mixture was stirred at room temperature, filtered through Celite, and extracted with ethyl acetate. Extract was evaporated to give 0.48 g of (-)-3a,5a-dihydroxy-2p-[3-(RS)-3-hydroxy-3-methyl-trans-octenyl]cyclopentane-l-a-acetaldehyde y-lactol 3-benzoate as an oil. 

Lithium chloride (2.6 g) is dissolved in THF (170 mL). Dimethyl-(2-oxo-4-phenylbutyl)phosphonate (7.87 g) and triethylamine (4.3 mL) are added. The mixture is stirred and cooled to -10°C. A solution of the Corey aldehyde benzoate, (lS,5R,6R,7R)-6-formyl-7-(benzyloxy)-2-oxabicyclo[3.3.0]octan-3-one (8.42 g) in THF (75 mL) is added to the reaction mixture over three hours. The resulting mixture is stirred for 18 hours at -10°C. At the end of this time, methyl t-butyl ether (MTBE) (100 mL) is added and the mixture warmed to 0-20°C. Sodium bisulfite (38%, 100 mL) is added and the two-phase mixture was stirred for 10 min. The phases are separated and the organic phase is washed with saturated aqueous sodium bicarbonate solution (100 mL). The organic phase is separated and concentrated under reduced pressure to a volume of <100 mL. Ethyl acetate (200 mL) is added and the... 

A crossed Claisen condensation is carried out by first adding the ester without a hydrogens to a solution of the alkoxide base. The ester with a hydrogens is slowly added to this solution, where it forms an enolate and condenses. The condensation of ethyl acetate with ethyl benzoate is an example of a crossed Claisen condensation. 

Propose a mechanism for the crossed Claisen condensation between ethyl acetate and ethyl benzoate. 

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