Ethanol, 2,2 dichloro

Ethane, 1-chloro-l-nitro-, 37, 25 1,2-Ethanedithiol, 30, 35 Ethanol, 2,2-dichloro-, 32, 46 Ethanolysis, 33, 25 Ether, benzhydryl 2-chloroethyl,... 

Cathodic cleavage 2.2.2- trichloro-l-(4-hydroxyphenyl)ethanol - 2.2- dichloro-l-(4-hydroxyphenyl)ethylene Japan 120 Pb cathode... 

Ding, Y., Fu, X. Theoretical study on the configuration of ethanol dichloro palladium [PdCl2(C2H40H)]. Chin. Chem. Lett. 1990, 1,183-184. 

Dimethoxytritylate compound 22 (2.90 g, 7.6 mmol) according to the procedure for preparing compound 5. Purify the crude product by column chromatography on silica gel (100 g). Elute initially with dichloromethane/ethyl acetate (1 1 by vol) containing 0.5% triethyl-amine, and then with a gradient of ethanol from 0 to 8% in ethyl acetate/triethylamine (199 1 by vol). Remove solvent from pure product fractions in vacuo to obtain the title compound as a solid white foam (5.14 g, 99%) of Ry O.15 on TLC in triethylamine/ethanol/dichloro-methane (1 5 94 by vol). 

In some instances a carbon-carbon bond can be formed with C-nucleophiles. For example, 3-carboxamido-6-methylpyridazine is produced from 3-iodo-6-methylpyridazine by treatment with potassium cyanide in aqueous ethanol and l,3-dimethyl-6-oxo-l,6-dihydro-pyridazine-4-carboxylic acid from 4-chloro-l,3-dimethylpyridazin-6-(lH)-one by reaction with a mixture of cuprous chloride and potassium cyanide. Chloro-substituted pyridazines react with Grignard reagents. For example, 3,4,6-trichloropyridazine reacts with f-butyl-magnesium chloride to give 4-t-butyl-3,5,6-trichloro-l,4-dihydropyridazine (120) and 4,5-di-t-butyl-3,6-dichloro-l,4-dihydropyridazine (121) and both are converted into 4-t-butyl-3,6-dichloropyridazine (122 Scheme 38). 

The example shown in Eq. (6.5) was conducted using 0.5 mole of bis-(2-mer-captoethyl) ether and 0.5 mole of 1,8-dichloro-3,6-dioxaoctane. The base was sodium hydroxide (1 mole) and between 900 and 2,000 mL of ethanol were used. The exact quantity of ethanol used in this synthesis is not clear from the experimental description. The reaction time was somewhere between 7 and 14 hours (again, unspecified), after which time the product (6) was isolated by vacuum distillation, as a viscous oil, in 27% yield. Similar approaches were utilized by this group for the synthesis of other analogs ". ... 

Dichloroquinoline with ethanolic potassium hydroxide (80°, 2 hr) gave equal amounts (31 and 32% yields) of 4- and 2-ethoxy-lation. In an earlier paper, only the 2-ethoxy product, in unspecifled yield,was reported. The reaction of the dichloro compound with... 

One route is described in U.S. Patent 2,986,573 Mix 63 grams of benzyl chloride, 38 grams of thiourea, 3 drops of concentrated ammonium hydroxide solution, and 250 ml of 95% ethanol. Reflux the mixture for 3 hours. Cool and add a solution containing 96 grams of 2,4-dichloro-nitrobenzene in 200 ml of ethanol. Heat the mixture to reflux and then add drop-wise a solution of 70 grams of potassium hydroxide in 500 ml of ethanol. Continue refluxing for 2 hours, and then cool and filter the solids produced. Wash the solid with aqueous ethanol and dry. There is thus produced 2-benzylthio-4-chloro-nitrobenzene. Sus-... 

To a stirred and refluxing solution of 40 parts of benzene and 35 parts of dimethylformamide (both solvents previously dried azeotropically) are added successively 1.6 parts of sodium hydride and 7.7 parts of Ct-(2,4-dichlorophenyl)imidazole-1-ethanol, (coolingon ice is necessary). After the addition is complete, stirring and refluxing is continued for 30 minutes. Then there are added 7.8 parts of 2,6-dichlorobenzyl chloride and the whole is stirred at reflux for another 3 hours. The reaction mixture is poured onto water and the product 1-[2,4-dichloro-/3 (2,6-dichlorobenzyloxy)phenethyl] imidazole, is extracted with benzene. The extract is washed twice with water, dried, filtered and evaporated in vacuo. The bese residue is dissolved in a mixture of acetone and diisopropyl ether and to this solution is added an excess of concentrated nitric acid solution. The precipitated nitrate salt is filtered off and recrystallized from a mixture of methanol and diisopropyl ether, yielding 1-[2,4-dichloro- (2,6-dichlorobenzyl-oxv)phenethyl] imidazole nitrate melting point 179°C. 

Apart from ethanol, other primary alcohols catalyse the formation of the dichloro complex, probably via a rhodium(I) intermediate rather than a rhodium(III) hydride. Rhpy4X2" compounds have anti-bacterial activity. 

A regio- and stereospecific INOC reaction of unsymmetrical silaketals 114, synthesized in one pot from unsaturated alcohols, nitro ethanol, and dichloro-silanes, via the nitrile oxide 115 to isoxazolines 116 has been described (Scheme 14) [37a]. The intermolecular version of the cycloaddition, under similar conditions, proceeds with poor regio and stereoselectivity. 

An extremely pure product results, when difluorochloro methane or difluoro-dichloro methane are used as solvents (79). Dichlorophosphoric acid is a fluid, colourless, very hygroscopic liquid, which is easily soluble in CHCI3, CCI4, Ethanol and Ether (6). In the liquid phase it is stable for some time at room temperature, whereas at 12 Torr there is no sign of decomposition up to 250 °C (6). According to the Raman spectra in the liquid it is dimeric in analogy to the carboxylic acids (20) ... 

Oda et al. reported that under reflux conditions, the zinc-promoted reaction of 2,3-dichloro-l-propene with aldehydes and ketones in a two-phase system of water and toluene containing a small amount of acetic acid gave 2-chloroallylation products (Eq. 8.31).64 No conversion occurred when tin was used as the promoter. The absence of water completely shuts down the reaction. Interestingly, the action of 2,3-dichloropropene plus zinc powder in aqueous ethanol gives the dechlorination product, allene.65... 

Scheme 3 shows the details of the synthetic strategy adopted for the preparation of heteroleptic cis- and trans-complexes. Reaction of dichloro(p-cymene)ruthenium(II) dimer in ethanol solution at reflux temperature with 4,4,-dicarboxy-2.2 -bipyridine (L) resulted the pure mononuclear complex [Ru(cymene)ClL]Cl. In this step, the coordination of substituted bipyridine ligand to the ruthenium center takes place with cleavage of the doubly chloride-bridged structure of the dimeric starting material. The presence of three pyridine proton environments in the NMR spectrum is consistent with the symmetry seen in the solid-state crystal structure (Figure 24). 

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