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Ethane-1 -hydroxy-1,1 -diphosphonate

Aminotrimethanephosphonic acid is formed from formamide, acetamide, urea, or alkanenitriles with phosphorous acid [296]. By reaction of monoalkyl phosphite or P406 with glacial acetic acid or the corresponding anhydride ethane-1 -hydroxy-1,1-diphosphonic acid is formed after hydrolysis [297,298]. P406 can be obtained from P4 and 02 in a high yield of 85-90% [299]. [Pg.568]

Ethane-1-hydroxy-1,1-diphosphonic acid is a substance widely used as a sequestering agent. Hence there are many methods developed for its large-scale preparation [106,107]. The substance was known as early as 1865 [79]. [Pg.576]

One process to form ethane-1-hydroxy-1,1-diphosphonic acid is the treatment of acetic acid with phosphorus trioxide [124] see Eq. (67) ... [Pg.576]

There are many methods for the preparation of ethane-1-hydroxy-1,1-diphosphonic acid including reacting phosphorus trichloride and acetic acid in the presence of tributylamine [106], phosphorus with acetic acid and oxygen [108], acetic anhydride with phosphorous acid and acetyl chloride [80,84-86,109,110], and acetic anhydride with phosphoric acid and acetic acid [111]. By another method ketene and phosphorous acid can be used [112], as shown in Eq. (68) ... [Pg.576]

Ethane-1-hydroxy-1,1-diphosphonate has a general inhibitory effect on the synthesis of various sulfated glycosaminoglycans, which caused no qualitative change in the glycosaminoglycan. [Pg.79]

ETHANEDIYL THIOCYANATE see EJC035 ETHANE HEXACHLORIDE see HCIOOO ETHANE, HEXANITRO- see HET675 ETHANEHYDRAZONIC ACID see ACM750 ETHANE-1 -HYDROXY-1,1 -DIPHOSPHONATE see HKS780... [Pg.1675]

ETHANE-1 -HYDROXY-1,1 -DIPHOSPHONIC ACID DISODIUM SALT see DXD400 ETHANENITRILE see ABE500 ETHANE, 1,1 -... [Pg.1675]

The administration of large amounts of ethane-1 -hydroxy-1,1 -diphosphonate (EHDP) has been shown to cause vitamin D-resistant rickets and a markedly repressed intestinal calcium absorption. This has also been shown to be due to a repressed 1,25-(OH)2D3 biosynthesis The repressed intestinal absorption brought by the large amount the EHDP can be completely reversed by the exogenous administration of l,25-(OH)2D3 It is unknown how the EHDP blocks the 1-hydroxylase, but it is not the result of direct inhibition ... [Pg.21]

Ethane-1-hydroxy-1,1-diphosphonic acid, tetrasodium salt. See... [Pg.1105]

CAS 3794-83-0 EINECS/ELINCS 223-267-7 Synonyms Ethane-1-hydroxy-1,1-diphosphonic acid, tetrasodium salt (1-Flydroxyethylidene) bisphosphonic acid, tetrasodium salt (1-Fly-droxyethylidene) diphosphonic acid, tetrasodium salt 1-Flydroxyeth-ylidene-1,1 -diphosphonic acid, tetrasodium salt NaiFIEDP Phosphonic acid, (1-hydroxyethylidene) bis-, tetrasodium salt Tetrasodium 1-hydroxyethane-1,1 -diphosphonate Tetrasodium (1 -hydroxyethylidene) bisphosphonate Tetrasodium 1 -hydroxyethylidene-1,1 -diphosphonate Classification Diphosphonic acid deriv. [Pg.1382]

Ethane hexachloride. See Hexachloroethane Ethane, hexafluoro-. See,Hexafluoroethane Ethane-1 -hydroxy-1,1 -diphosphonate. See Etidronic acid... [Pg.1664]

Ethane-1 -hydroxy-1 -1 di phosphonic acid disodium salt. See. Disodium etidronate Ethane-1 -hydroxy-1,1 -diphosphonic acid, tetrasodium salt. See Tetrasodium etidronate Ethane, 1,1 -[methylenebis (oxy)] bis-. See Diethoxymethane... [Pg.1664]

Synonyms Ethane-1-hydroxy-1,1-diphosphonic acid, tetrasodium salt (1-Hydroxyethylidene) bisphosphonic acid, tetrasodium salt (1-Hydroxyethylidene) diphosphonic acid, tetrasodium salt 1-Hydroxyethylidene-1,1-diphosphonic acid, tetrasodium salt Na4HEDP... [Pg.4395]

C2H10N8O2P2S2 r trans-3,6-Dimethoxy-1,2,4,5-tetraaza-3,6-diphospha-cyclohexane 3,6-disulfide, 46B, 652 C2Hio08P2f Ethane-1-hydroxy-1,1-diphosphonic acid monohydrate, 38B, 651... [Pg.324]

Larsson, S. E. The metabolic heterogeneity of glycosaminoglycans of the different zones of the epiphyseal growth plate and the effect of ethane-l-hydroxy-l,l-diphosphonate (EHDP) upon glycosaminoglycan synthesis in vivo. Calc. Tiss. Res. 21, 67 (1976)... [Pg.129]

Schenk, R., et al. Effect of ethane-l-hydroxy-1, 1-diphosphonate (EHDP) and dichlor-methylene diphosphonate (CI2 MDP) on the calcification and resorption of cartilage and bone in the tibial epiphysis and metaphysis of rats. Calc. Tiss. Res. 77, 196 (1973)... [Pg.140]

With stirring and under reflux, 8.6 g (0.053 mole) of imidazol-4-yl acetic acid hydrochloride, 7.1 ml of 85% phosphoric acid and 25 ml of chlorobenzene are heated to 100°C. Then 13.9 ml of phosphorus trichloride are added dropwise at 100°C, whereupon evolution of gas occurs. Over the course of 30 min a dense mass precipitates from the reaction mixture. The batch is heated for 3 hours to 100°C and the supernatant chlorobenzene is removed by decantation. With stirring and under reflux, the residual viscous mass is heated to the boil for 3 hours with 40 ml of 9 N hydrochloric acid. The batch is filtered hot with the addition of carbon and the filtrate is diluted with acetone, whereupon the crude 2-(imidazol-4-yl)-l-hydroxy-ethane-l,l-diphosphonic acid precipitates. This product is recrystallised from water. Melting point 238-240°C (dec.). [Pg.3560]

SYNS DIDRONELR DISODIUM DIHYDROGEN-(l-HYDROXYETHYLIDENE)DIPHOSPHONATE DISODIUM ETHANOL-1,1-DIPHOSPHONATE DISODIUM ETHYDRONATE EITDRONATE DISODIUM ETHANE-l-HYDROXY-l,I-DIPHOSPHON-IC ACID DISODIUM SALT (1-HYDROXYETHYL-IDENE)DIPHOSPHONIC ACID DISODIUM SALT SODIUM ETHIDRONATE SODIUM ETHYDRONATE... [Pg.572]

EtidroniC Acid. (1 -Hytlroryctliyliden t liityiioi, phonic acid (l-bydroxyethylidene)diphosphonic acid ethane-1-hydroxy-1,1-dipbospbonic acid EHDP. C2H8-... [Pg.606]

Synonyms Disodium dihydrogen (1-hydroxyethylidene) diphosphonate Disodium ethanol-1,1-diphoshonate Disodium ethydronate Ethane-1-hydroxy-1-Idiphosphonic acid disodium salt Etidronate disodium... [Pg.1530]

Ethane-l-hydroxy-1,1 diphosphonate (EHDP) (12.125a) and related bis-phosphonate compounds such as (12.125b-f) inhibit bone resorption and are used in the treatment of osteoporosis and other bone diseases [9,10]. [Pg.1119]

Corrosion Inhibition by l-Hydroxy-Ethane-I,l-Diphosphonic Acid... [Pg.471]

Corrosion Inhibition by 1-Hydroxy-Ethane-1,1-Diphosphonic Acid (HEDP)... [Pg.481]

The adsorption of 1-hydroxy-ethane-1,1-diphosphonic acid (HEDP) with Ca " or cation additives on a spontaneously oxidized mild steel surface was examined in order to study the effect of these cations on the adsorption mechanism in neutral aqueous solutions. Quantitative XPS investigations were performed to study the effect of increasing the calcium and zinc concentrations on the adsorption of HEDP. [Pg.524]

See other pages where Ethane-1 -hydroxy-1,1 -diphosphonate is mentioned: [Pg.601]    [Pg.116]    [Pg.601]    [Pg.601]    [Pg.1784]    [Pg.1383]    [Pg.324]    [Pg.601]    [Pg.116]    [Pg.141]    [Pg.141]    [Pg.141]    [Pg.974]    [Pg.1519]    [Pg.974]    [Pg.227]    [Pg.601]    [Pg.7119]    [Pg.601]    [Pg.477]    [Pg.383]    [Pg.1784]    [Pg.1383]    [Pg.313]    [Pg.324]    [Pg.474]    [Pg.546]   
See also in sourсe #XX -- [ Pg.227 ]



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