Estraderm® system

The same technology has been utilized in the development of the following 1) the Estraderm system, which administers a controlled dose of estradiol transdermally over 3 days for the relief of postmenopausal syndrome and osteoporosis 2) the Duragesic system, which provides a transdermal-controlled administration of fentanyl, a potent narcotic analgesic, for 72-h relief of chronic pain and 3) the Androderm system, which provides a transdermal-controlled delivery of... 

FIGURE 52-1. This low-dose estrogen transdermal patch, available as the trade name Estraderm (Estradiol Transdermal System), is transparent and about the size of a silver dollar. It releases small amounts of estrogen directly into the bloodstream at a constant and controlled rate to a female requiring estrogen replacement therapy for postmenopausal symptoms. 

There are several FDA-approved estradiol patches currently on the market. These patches are three- to four-day patches used to treat symptoms associated with menopause. Estraderm is the only membrane-moderated estradiol system that is on the market. Estraderm is available in two sizes 0.05 and 0.1-mg/day patches. Vivelle, Vivelle Dots, Alora, and Climara are examples of commercially available estradiol patches that utilize adhesive matrix patch design. 

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