Erythropoietin-receptor activators

Macdougall IC (2005) CERA (Continuous Erythropoietin Receptor Activator) a new erythropoiesis-stimulating agent for the treatment of anemia. Curr Hematol Rep 4 436-440... 

Pegzerepoetin alfa (also known as methoxy polyethylene glycol-epoetin beta) is a continuous erythropoietin-receptor activator that is licensed for... 

Remy, L, Wilson, I. A., and Michnick, S. W. (1999). Erythropoietin receptor activation by ligand-induced conformation change science. Science 283, 990-993. 

Remy I, Wilson I, Michnick S. Erythropoietin receptor activation by a ligand-induced conformation change. Science 1999 283 990-993. 

Lasne, F., Martin, L., Martin, J.A., and de Ceaurriz, J. (2009) Detection of continuous erythropoietin receptor activator in blood and urine in anti-doping control. Haematologica, 94, 888-890. 

Erythropoietin stimulates erythroid proliferation and differentiation by interacting with erythropoietin receptors on red cell progenitors. The erythropoietin receptor is a member of the JAK/STAT superfamily of cytokine receptors that use protein phosphorylation and transcription factor activation to regulate cellular function (see Chapter 2). Erythropoietin also induces release of reticulocytes from the bone marrow. Endogenous erythropoietin is primarily produced in the kidney. In response to tissue hypoxia, more erythropoietin is produced through an increased rate of transcription of the... 

Wilson, I. A., and Jolliffe, L. K. (1999). The structure, organization, activation, and plasticity of the erythropoietin receptor. Cure. Opin. Struct. Biol. 9, 696-704. 

Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation. Science 283(5404), 987-990. 

Membrane Receptors with Associated Tyrosine Kinase Activity Erythropoietin Receptor... 

Constantinescu, S.N., Ghaffari, S. and Lo-dish, H.F. (1999) The Erythropoietin Receptor Structure, Activation and Intracellular Signal Transduction. Trends Endocrin-ol.Metab, 10, 18-23. 

Livnah, O., Stura, E.A., Middleton, S.A., Johnson, D.L., Jolliffe, L.K. and Wilson, I.A. (1999) Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation. Science, 283, 987 - 990. 

Constantinescu, S. N., S. Ghaffari, and H. F. Lodish. 1999. The erythropoietin receptor structure, activation, and intracellular signal transduction. Trends Endocrin. Metab. 10 8-23. 

B., Miura, O. and Ihle, J.N. (1993) JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell 74 227-236. 

Seubert, N., Royer, Y., Staerk, J., Kubatzky, K. F., Moucadel, V., Krishnakumar, S., Smith, S. O., and Constantinescu, S. N. (2003). Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer. 

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