Erythrocyte invasion Plasmodium falciparum

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Mitchell, G. H., Hadley, T. J., McGinniss, M. H., Klotz, F. W., and Miller, L. H. (1986). Invasion of erythrocytes by Plasmodium falciparum malaria parasites Evidence for receptor heterogeneity and two receptors. Blood 67,1519-1521. 

Roggwiller, E., Betoulle, M. E., Blisnick, T., and Braun Breton, C. (1996). A role for erythrocyte band 3 degradation by the parasite gp76 serine protease in the formation of the para-sitophorous vacuole during invasion of erythrocytes by Plasmodium falciparum. Mol. Biochem. Parasitol. 82,13-24. 

Hossain ME, Dhawan S, Mohmmed A (2012) The cysteine-rich regions of Plasmodium falciparum RON2 bind with host erythrocyte and AMA1 during merozoite invasion. Parasitol Res 110(5) 1711- 1721... 

Duraisingh, M. T., Maier, A. G., Triglia, T., and Cowman, A. F. (2003). Erythrocyte-binding antigen 175 mediates invasion in Plasmodium falciparum utilizing sialic acid-dependent and -independent pathways. Proc. Natl. Acad. Sci. USA 100,4796 801. 

Gaur, D., Singh, S., Singh, S., Jiang, L., Diouf, A., and Miller, L. H. (2007). Recombinant Plasmodium falciparum reticulocyte homology protein 4 binds to erythrocytes and blocks invasion. Proc. Natl. Acad. Sci. USA 104,17789-17794. 

Rayner, J. C., Vargas-Serrato, E., Huber, C. S., Galinski, M. R., and Barnwell, J. W. (2001). A Plasmodium falciparum homologue of Plasmodium vivax reticulocyte binding protein (PvRBPl) defines a trypsin-resistant erythrocyte invasion pathway. ]. Exp. Med. 194, 1571-1581. 

Mikkelsen, R. B., Kamber, M., Wadwa, K. S., Lin, P.-S. and Schmidt-Ullrich, R. (1988) The role of lipids in Plasmodium falciparum invasion of erythrocytes a coordinated biochemical and microscopical analysis. Proc. Natl. Acad. Sci. USA 85 5956-5960. 

Malaria parasites have a complex life cycle that permits drug action at several points. Plasmodium species that infect humans P falciparum, P malariae, P ovale, P vivax) tire spread by the female Anopheles mosquito and, after inoculation into the human host, undergo a primary developmental stage in the liver (primary tissue phase). They then enter the blood and parasitize erythrocytes (erythrocytic phase). P falciparum and P malariae have only one cycle of liver cell invasion thereafter, multiplication is confined to erythrocytes. The other species have a dormant hepatic stage (in which they become bypnozoites) that is responsible for recurrent infections and relapses after apparent recovery of the host from the initial infection. 

Fleck SL, Birdsall B, Babon J, Dluzewski AR, Martin SR, Morgan WD, Angov E, Kettleborough CA, Feeney J, Blackman MJ, Holder AA, Suramin and suramin analogues inhibit merozoite surface protein-1 secondary processing and erythrocyte invasion by the malaria parasite Plasmodium falciparum, J. Biol. Chem. 2003 278 47670-47677. 

Klotz, F.W., Orlandi, P.A., Reuter, G., Cohen, S.J., Haynes, J.D., Schauer, R., Howard, R.J., Palese, P., and Miller, L.H. Binding of Plasmodium falciparum 175 kilodalton erythrocyte binding antigen and invasion of murine erythrocytes requires A-acetylneuraminic acid but not... 

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