Ergot alkaloids Ergotamine

Ergot alkaloids (ergotamine, ergonovine) also exhibit certain nonselective a-adrenoblocking activity however, they primarily exhibit spasmogenic action on smooth muscle, causing a constriction of blood vessels. 

Protoplasts of C. purpurea have been prepared which are able to synthesize the peptidic ergot alkaloids ergotamine (69) and ergocryptine de novo.63 Various radioactive amino-acids were incorporated into the alkaloids, and D-lysergic acid (70) stimulated their utilization. It was the only precursor to stimulate the synthesis of alkaloids, and the proposal was made that the concentration of (70) in the cells is a rate-limiting factor in alkaloid synthesis. 

TRIPTANS ERGOT ALKALOIDS- ERGOTAMINE, METHYSERGIDE T risk of vasospasm Additive effect 1. Do not administer ergotamine and almotriptan, rizatriptan, sumatriptan or zolmitriptan within 6 hours of each other 2. Do not administer methy-sergide and almotriptan, rizatriptan, sumatriptan or zolmitriptan within 24 hours of each other 3. Do not administer an ergot derivative and eletriptan or frovatriptan within 24 hours of each other... 

VORICONAZOLE ERGOT ALKALOIDS -ERGOTAMINE t ergotamine/methysergide levels, with risk of toxicity Inhibition of metabolism of the ergot derivatives Avoid co-administration. If absolutely necessary, advise patients to discontinue treatment immediately if numbness and tingling of the extremities are felt... 

Clinically important, potentially hazardous interactions with aprepitant, astemizole, carbamazepine, colchicine, cyclosporine, dihydroergotamine, ergot alkaloids, ergotamine, erythromycin, fluoxetine, fluvoxamine, methylprednisolone, methysergide, oral contraceptives, paroxetine, pimozide, prednisolone, rifampicin, sertraline, solifenacin, terfenadine, warfarin... 

Six ergot alkaloids (ergotamine and an isomer and five hydroxylated metabolites) were extracted from the fungus Claviceps and baseline resolved on a Cjg column k = 250 nm, ex 370 nm long-pass filter). A 90/10 60/40 (at 15 min hold 7 min)... 

Floss, H.G., Basmadjian, G.P., Tcheng, M., Spalla, C. and Minghetti, A. (1971a) Biosynthesis of peptide-type ergot alkaloids. Ergotamine. Lloydia, 34,442—445. 

A distinct trend can be seen in the use of ergot alkaloids in the last few decades. While the therapentic nse of classical ergot alkaloids (ergotamine. 

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