Epithelial/epithelium cells

Other cell lines used in permeability studies include the T84 human colonic adenocarcinoma colonic crypt cell model. This line has a reduced carrier expression, secrets mucus, and has very high resistance [31, 32], The IEC cell line is a rat fetal intestinal epithelium cell with higher permeabilities than Caco-2 cells [33], LLC PKi is a pig kidney epithelial cell line with low expression of efflux systems, but expression systems for transport proteins [32], 2/4/A1 cells are a conditionally immortalized rat fetal intestinal epithelium line with crypt cell-like morphology and temperature-sensitive differentiation [34], They form differentiated monolayers with tight junctions, increased brush border enzymes when grown on extracellular matrices with laminin. Transport of drugs with LP in 2/4/A1 monolayers was comparable to that in the human jejunum and up to 300 times faster than that in Caco-2 monolayers. In contrast, the permeability of HP drugs was comparable in both cell lines [34],... 

Epithelial, epithelium The layers of cells and connecting tissues that form the covering of internal and external body surfaces, including the lining of small vessels and cavities. 

A complete comeal ulcer is a sign of the seriousness of a bum. The theory of the limbal stem cells may explain that experimental fact. Actually, in that theory, those cells, which are the only ones to regenerate some mature epithelial comeal cells, would be located around the comeal epithelium. Like the conjunctival ischemia, the complete comeal ulcer is an indirect sign of probable destmction of the limbal stem cells. Nevertheless, a complete comeal ulcer or a comeal ulcer that completely releases the optical axis, does not cause any loses of visual acuity. 

The lung contains more than 40 different types of cells, amongst which epithelial cells are vital for maintenance of the pulmonary blood-gas barrier. The epithelium also provides absorptive and secretive functions. The diversity of epithelial cell types is summarized as airway epithelium and alveolar epithelium cells. 

McWilliam, A. S., Marsh, A. M., and Holt, P. G. (1997) Inflammatory infiltration of the upper airway epithelium during Sendai virus infection involvement of epithelial dendritic cells. J. Virol. 71, 226-236. 

The rate of protein clearance has been estimated as 10% of the rate of fluid clearance from alveoli [173]. IgG clearance is probably mediated by FcRn transcytosis in distal type I alveolar epithelium and more proximal bronchial epithelium. Type I alveolar epithelium and bronchial epithelium contain the necessary subcellular structures for FcRn-mediated transcytosis vesicles, membrane invaginations, caveolae, and clathrin-coated pits [173,174], FcRn mRNA is expressed in lung although the cell types and locations have not yet been determined [112], Moreover, primary alveolar epithelial monolayer cell cultures express functional FcRn [173], plgA-R/SC transcytosis is thought to contribute little to distal (alveolar) airway IgG transport but might mediate more proximal (bronchial or bronchiolar) IgA transport [173], Uptake of an aerosolized IgG Fc-erythropoietin fusion molecule and subsequent erythropoietin-induced reticulocytosis has been demonstrated in human and nonhuman primates [175],... 

With the exception of FGFR4, mRNA for all other three receptors have been reported to be present in the normal human prostate (13). In contrast to the prostatic stromal cells, which mainly secrete FGF7 and to a lesser extent FGF2 and FGF1, the epithelium cells do not produce any FGF. Flowever, both stromal and epithelial cells express FGFR isoforms (Fig. 8) and therefore it can be proposed that the... 

Barrier function is also supported by the gastrointestinal immune system much of the epithelium is bathed in immunoglobulin A (IgA), which is secreted from sub-epithelial plasma cells and transcytosed across the epithelium into the lumen. IgA provides an antigenic barrier by binding bacteria and other antigens, although this barrier function is specific for particular antigens and requires previous exposure for development of the response. 

Basal cells that stop dividing also stop secreting a basal lamina and lose their attachment. They are squeezed by adjacent, dividing basal cells into the body of the junctional epithelium and are expelled into the base of a sulcus. The few tight junctions in the body of the junctional epithelium are consistent with its permeability to interstitial fluid. The rapidly dividing cells of both internal and external basal layers express K5 and K14 like all stratified epithelial basal cells, but the interior cells express K4 and K13, not K1 and K10 (Fig. 5.11). The composition of the internal basal lamina is described in Fig. 5.7b. 

Feuerhake, F., Sigg, W., Hofter, E. A., Dimpfl, T., Welsch, U. (2000) Immu-nohistochemical analysis of Bcl-2 and Bax expression in relation to cell turnover and epithelial differentiation markers in the non-lactating human mammary gland epithelium. Cell Tissue Res. 299,47-58. 

The epithelial basal cell is characterized by its small amount of cytoplasm in relationship to its relatively large nucleus. It is present mainly in large airways and is believed to be the stem cell or precursor cell of the tracheal epithelium and able to differentiate into other epithelial cell types. The intermediate cell, which is columnar and extends from the basement mem-... 

In general, the external and Internal surfaces of organs are covered by a sheetlike layer of epithelial tissue called an epithelium. Cells that form epithelial tissues are said to be polarized because their plasma membranes are organized Into at least two discrete regions. Typically, the distinct surfaces of a polarized epithelial cell are called the apical (top), basal... 

Detection of myoepithelial Squamous epithelium, cells in prostatic carcinoma basal epithelial cells, myoepithelial cells, mesothehal cells, cornea... 

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