Epithelial cells, ozone effects

Epinephrine, chemiluminescence, 647 6-Epiplakortolide E, synthesis, 256, 257 Epithelial cells, ozone effects, 612 Epothilone B, dioxirane epoxidation synthesis, 1145... 

Active oxygen species, especially hydrogen peroxide and probably hydroxyl radical, play a role in particle uptake in the tracheobronchial epithelium and possibly in the alveolar epithelium. Surface iron on the particle is one important factor in this process. The normal production of small amounts of hydrogen peroxide by pulmonary epithelial cells may serve as an accidental autocrine mechanism that increases uptake, and release of AOS ITom particle-evoked inflammatory cells may well have the same effect. Exogenous sources of AOS (e.g., ozone and cigarette smoke) greatly enhance uptake of many particles and probably potentiate mineral dust-induced pathological reactions. 

Hotchkiss, J.A., Harkema, J.R. and Henderson, R.F. (1991). Effect of cumulative ozone exposure on ozone-induced nasal epithelial hyperplasia and secretory cell metaplasia in rats. Exp. Lung Res. 15, 589-600. 

The sites of action and effects of ozone and other photochemical oxidants are described in Chapters 8 and 9. Recent work with primates has suggested that ozone is absorbed along the entire respiratory tract, penetrates more into the peripheral nonciliated airways, and causes more lesions in the respiratory bronchioles and alveolar ducts as the inhaled ozone concentration increases from 0.2 to 0.8 ppm. The most common and most severe tissue damage was observed in the respiratory bronchioles. The ciliated cells in the terminal bronchioles and the Type 1 cells in the epithelial layer of the proximal alveoli of rats were the... 

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