Epinephrine, chemiluminescence

Epinephrine, chemiluminescence, 647 6-Epiplakortolide E, synthesis, 256, 257 Epithelial cells, ozone effects, 612 Epothilone B, dioxirane epoxidation synthesis, 1145... 

The 02, radical can act as an oxidant as well as a reductant and chemical estimates of its production can also be based on its ability to oxidize epinephrine to adren-ochrome [62], These chemical methods have the additional advantage of not requiring highly specialized equipments. Also based on its redox property, the 02 radical can be determined by chemiluminescence methods through the measurement of the intensity of the fluorescence radiation emitted after chemical oxidation of 02 by, e.g., lucigenin [63-67], These methods, however, are limited by the poor selectivity and lack of capability for in-vivo performance. 

Lei et al. and Nie et al. [110, 111] have reported two assays for indapamide and indomethacin, respectively, also based on luminol as chemiluminescent reagent. Again MAA and EGDMA were used as monomers and acetonitrile as porogen. Excellent detection limits were achieved 10 x M for indapamide and indomethacin in urine and 10-9 M for epinephrine in serum. The authors describe the crossreactivity for other contaminants potentially present in urine such as antibiotics (norfloxacin), ions (Fe2+, Ca2+, K+), or glucose. 

Kamidate T, Kaide T, Tani H, Makino E, Shibata T. Effect of mixing modes on chemiluminescent detection of epinephrine with lucigenin by an FIA system fabricated on a microchip. Anal Sci 2001 17 951-955. 

Higashidate, S. Imai, K. Prados, P Adachi-Akahane, S. Nagao, T. Relations between blood pressure and plasma norepinephrine concentrations after administration of diltiazem to rats HPLC-perox-yoxalate chemiluminescence determination on an individual basis. Biomed.Chromatogr, 1994, 8, 19-21 [plasma extracted diltiazem, dopamine, epinephrine, norepinephrine rat chemiluminescence detection SPE]... 

Zheng XW, Guo ZH, Zhang ZJ (2001) Flow-injection electrogenerated chemiluminescence determination of epinephrine using luminol. Anal Chim Acta 441(l) 81-86. doi 10.1016/ s0003-2670(01)01090-x... 

J.X. Du, L.H. Shen and J.R. Lu, Flow injection chemiluminescence determination of epinephrine using epinephrine-imprinted polymer as recognition material. Anal. Chim. Acta, 489 (2) 183-189, 2003. 

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