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Epilepsy adenosine

A number of studies have shown that adenosine inhibits neuronal firing both in vitro and in vivo and is itself released during intense neuronal activity. It can protect against PTZ seizures in rodents while the antagonist theophylline is proconvulsant. No clear picture of its role in human epilepsy has emerged. [Pg.341]

Knutsen LJS, Murray TF. Adenosine and ATP in epilepsy. In Jacobson KA, Jarvis MF, eds. Purinergic Approaches in Experimental Therapeutics. New York Wiley-Liss, 1997 423 447. [Pg.248]

Recently, the therapeutic potential of stem cells engineered to release adenosine as a local source to augment endogenous adenosinergic functions was assayed in two cell transplantation experiments (Li et al. 2007, 2008 Boison 2008). Most of the studies about the role of adenosine as an anticonvulsant emphasize the preeminent involvement of A1 adenosine receptors. However, several studies using different experimental models of epilepsy have investigated the role of adenosine A2a and A3 receptors in this condition. [Pg.170]

Latini S, Pedata F (2001) Adenosine in the central nervous system release mechanisms and extracellular concentrations. J Neurochem 79(3) 463 184 Laudadio MA, Psarropoulou C (2004) The A3 adenosine receptor agonist 2-C1-IB-MECA facilitates epileptiform discharges in the CA3 area of immature rat hippocampal slices. Epilepsy Res 59(2—3) 83—94... [Pg.184]

Vianna EP, Ferreira AT, Dona F, Cavalheiro EA, Silva Fernandes MJ (2005) Modulation of seizures and synaptic plasticity by adenosinergic receptors in an experimental model of temporal lobe epilepsy induced by pilocarpine in rats. Epilepsia 46(Suppl 5) 166-173 Volpini R, Costanzi S, Lambertucci C, Taffi S, Vittori S, Klotz KN, Cristalli G (2002) N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands. J Med Chem 45(15) 3271-3279... [Pg.187]

Despite early studies suggesting that the acetylcholine concentration was raised in epileptogenic foci, which would be consistent with the finding that anticholinesterases cause seizures in both animals and man, it now appears that overactivity of the central cholinergic system is unlikely to be the cause of seizures in the human epileptic. Other candidates that have been implicated in the aetiology of epilepsy include adenosine and the enkephalins, but conclusive evidence for their involvement is presently lacking. [Pg.301]

Much current interest stems from pharmacological rather than physiological observations. Adenosine can act presynaptically throughout the cortex and hippocampal formation to inhibit the release of amine and amino acid transmitters. ATP-regulated responses have been linked pharmacologically to a variety of supracellular functions, including anxiety, stroke, and epilepsy. [Pg.218]


See other pages where Epilepsy adenosine is mentioned: [Pg.538]    [Pg.168]    [Pg.170]    [Pg.245]    [Pg.96]    [Pg.757]    [Pg.757]    [Pg.279]    [Pg.196]    [Pg.4129]    [Pg.156]   
See also in sourсe #XX -- [ Pg.341 ]




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