Stem cell engineering

Stem Cell Engineering for Cell-Based Therapy... 

Reproduced with permission from the Institute of Physics Publishing Ltd. Taupin, P. Stem cell engineering for cell-based therapy. Journal of Neural Engineering (2007) 4(3) R59-63. Copyright 2007, the Institute of Physics Publishing Ltd. http //jne.iop.org. 

Recently, the therapeutic potential of stem cells engineered to release adenosine as a local source to augment endogenous adenosinergic functions was assayed in two cell transplantation experiments (Li et al. 2007, 2008 Boison 2008). Most of the studies about the role of adenosine as an anticonvulsant emphasize the preeminent involvement of A1 adenosine receptors. However, several studies using different experimental models of epilepsy have investigated the role of adenosine A2a and A3 receptors in this condition. 

In particular, stem cell engineering is still a highly contentious issue hotly debated among various segments of the population, by politicians as well as by ethically concerned self-appointed activists. Rapid and predictive in vitro test methods for bioceramics-cell responses could largely alleviate the use of costly and ethically compromised animal experiments. Both are challenging aspects of future bioceramics research and development. 

B.2.3.1 Stem Cell Engineering hi the overall field of biotherapeutics, stem cell engineering is a major area of current research. In view of its growing importance, a brief overview of this subject is presented in the following. 

Monk J. (2010) Stem cell engineering. Chem. Eng. Prog., 106(11) 35-36. 

Stem cell engineering including marrow stem cell (MSC) therapy. 

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