Epilepsies imaging

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This work was supported by the Ontario Brain Institute (OBI)— Eplink The OBI Epilepsy Project (MDT) The National Science and Engineering Research Council (NSERC) and the Dairy Farmers of Canada (DFC). The Canadian Institutes of Health Research (CIHR), The Scottish Rite Charitable Foundation of Canada, and Epilepsy Canada supported the work of Miles Thompson. We thank Dr. Craig Behnke for permission to adapt the image presented in Fig. 1. 

Noebels Exactly, and the dysmyehnation could be a lot more severe than what we see by magnetic resonance imaging. That is an interesting point. In fact, I don t know this patient population very weU. It is not clear that they all have epilepsy or severe demyelination. It is not a homogeneous syndrome. It will be interesting to find out what kind of variability there is, and whether it corresponds to heterozygous effectors. 

SPECT scans measure radiotracer uptake by tissues and provide cross-sectional images of the brain. This technique has been used extensively to assess cerebral blood flow. Although the resolution of SPECT is not as good as PET, the availability has led to wide clinical use in disorders such as stroke, dementia, and epilepsy. 

Seizures result from the sudden, excessive firing of neurons. They are classified broadly as either partial seizures, in which the abnormal firing initially occurs in a small number of neurons but may spread to adjacent areas, or generalized seizures, in which virtually the entire brain is affected simultaneously (11). Seizures can be characterized by clinical symptoms and by EEC patterns. In addition, computed tomography and magnetic resonance imaging of the head are used in virtually all patients with suspected epilepsy to aid in identifying the seizure type. 

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