Epilepsy magnetic resonance imaging

F. Andermann, and D.L. Arnold. 2001. Texture analysis and morphological processing of magnetic resonance imaging assist detection of focal cortical dysplasia in extra-temporal partial epilepsy. Ann. Neurol. 49 770-775. 

Noebels Exactly, and the dysmyehnation could be a lot more severe than what we see by magnetic resonance imaging. That is an interesting point. In fact, I don t know this patient population very weU. It is not clear that they all have epilepsy or severe demyelination. It is not a homogeneous syndrome. It will be interesting to find out what kind of variability there is, and whether it corresponds to heterozygous effectors. 

Seizures result from the sudden, excessive firing of neurons. They are classified broadly as either partial seizures, in which the abnormal firing initially occurs in a small number of neurons but may spread to adjacent areas, or generalized seizures, in which virtually the entire brain is affected simultaneously (11). Seizures can be characterized by clinical symptoms and by EEC patterns. In addition, computed tomography and magnetic resonance imaging of the head are used in virtually all patients with suspected epilepsy to aid in identifying the seizure type. 

Paolicchi JM, Thiele EA, Zupanc ML, Collins SD. Magnetic resonance imaging abnormalities associated with vigabatrin in patients with epilepsy. Epilepsia 2009 50(2) 195-205. 

Simister, R. J., Woermann, F. G., McLean, M. A. et al. A short-echo-time proton magnetic resonance spectroscopic imaging study of temporal lobe epilepsy. Epilepsia 43 1021-1031, 2002. 

Stanfield, B.B. 1989. Excessive intra- and supragtanular mossy fibers in the dentate gyrus of tottering (tg/tg) mice. Brtiin Res 480(l-2) 294—299 Stanley, J.A., Cendes, F., Dubeau, F., Andermann, F., and Arnold, D.L. 1998. Proton magnetic resonance spectroscopic imaging in patients with extratemporal epilepsy. Epilepsia 39(3) 267-273... 

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