Epidermoid cancer/carcinoma cell lines

In ME-180, a human cervical epidermoid carcinoma cell line, and KYM-1, a human myosarcoma cell line, which are TNF sensitive, Mn-SOD levels are one order of magnitude lower than in TNF-resistant cells. However, ZR-75-1, a human breast cancer cell line that is also TNF sensitive, contains a relatively high level of Mn-SOD, even though its level is not as high as those of TNF-resistant cells. The basal Mn-SOD protein levels in KYM-1 and ME-180 cells are very low, and... 

Pinus densifiora Sieb. et Zucc. (Pinaceae) EO inhibited proliferation and induced apoptosis in YD 8 cells (human oral squamous carcinoma). Cell proliferation was inhibited by 30% and 60% at concentrations of 40 and 60 pg/mL EO. The EO reduced cancer cells by 70% when treated with 60 pg/mL EO. Apoptosis was induced by activation of caspase-9 (Jo et al., 2012). Soeur et al. (2011) found ihdXAniba rosaeodora Ducke (Lauraceae) had cytotoxic effects against A431 (human epidermoid carcinoma cell line) and on HaCaT (human keratinocytes) cells. At a concentration... 

Vatdiospyrodol C (93) from Vatica diospyroides displayed the most potent activity against oral epidermoid carcinoma (KB, EC50 1.0 pg-ml"1), colon cancer (CoI2, EC50 1.9 pgml 1), and breast cancer (BC1, EC50 3.8 pg-ml 1) cell lines. This is the first example in which significant cytotoxic... 

PTX-2 was toxic to KB (human epidermoid carcinoma) cells in vitro at a concentration of 58 nM [14]. In contrast, no evidence of a toxic effect in these cells was seen with PTX-2 seco acid or l-epi-VTX-2 seco acid at a concentration of 2 pM [14]. PTX-2 has been screened for selective cytotoxic activity against 60 human tumour cell lines by the US National Cancer Institute. It was selectively toxic to several cell lines of ovarian, renal, pulmonary, colonic, cerebral, and mammary tumors at nanomolar concentrations, but was ineffective against leukemia or prostate cancer cell lines [37]. PTX-2 was toxic to Vero (monkey renal epithelial) cells at a concentration of 0.58 pM... 

Antitubercular and antimalarial activity-guided study of the roots of Artocarpus altilis led to the isolation of nine prenylated flavones. Cycloartocarpin (1), Artocarpin (2), and Chaplashin (3) were isolated from the CH2CI2 extract of the root stems, whereas Morusin (4), Cudraflavone (5), Cycloartobiloxanthone (6), Artonin (7), Cudraflavone (8) and Artobiloxanthone (9) were found in the root barks. The isolated compoimds exhibited antitubercular and antiplasmodial activities, and also showed moderate cytotoxicity against KB (human oral epidermoid carcinoma) and BC (human breast cancer) cell lines [33-34]. 

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