Epidemiology controversy

Cotton Dust Exposure and Chronic Respiratory Impairment An Epidemiological Controversy... 

Horwitz RI, Feinstein AR. Estrogens and endometrial cancer. Responses to arguments and current status of an epidemiologic controversy. Am J Med 1986 81(3) 503-7. 

Nuclear Proximity and the Epidemiological Controversies of Leukemia in La Hague... 

There has been some controversy over the effect of traces of anesthehc gases in the operating room on the health of personnel working there daily Numerous animal studies usmg low levels of anestheltic gases have failed to show any effects, and several epidemiological studies show that human health is not affected by traces of anesthetic gases [20]... 

The lARC has concluded that epidemiological studies have established the relationship between benzene exposure and the development of acute myelogenous leukemia and that there is sufficient evidence that benzene is carcinogenic to humans. Although a benzene-leukemia association has been made, the exact shape of the dose-response curve and/or the existence of a threshold for the response is unknown and has been the source of speculation and controversy. Some risk assessments suggest exponential increases in relative risk (of leukemias) with increasing cumulative exposure to benzene. At low levels of exposure, however, a small increase in leukemia mortality cannot be distinguished from a no-risk situation. In addition to cumulative dose other factors such as multiple solvent exposure, familial connection, and individual sus-... 

Furthermore, polyphenolics present in wine, of which flavonoids are important components, have been suggested to be responsible of the so called French paradox, that is, the unexpectedly low rate of mortality from coronary heart disease in French population despite an unfavourable exposure to known cardiovascular risk factors such as high saturated fat consumption [19-21]. Epidemiological studies in USA [22] and Denmark [23] reported that moderate red wine drinkers had a lower risk of coronary artery disease than participants with no alcoholic beverage preference. However, controversial results about the antioxidant capacity of human serum after red wine consumption have been reported [24-27]. It is therefore uncertain whether wine constituents other than alcohol add to the cardioprotective effects of red wine. 

Saccharin is noncaloric and noncariogenic (2,3). The safety of saccharin for public health has been the center of several controversies. In 1970, saccharin at high dietary levels was observed to increase the incidence of urinary bladder cancer in experimental rats (1,59). However, extensive human epidemiological investigations showed that use of saccharin does not significantly increase the risk of bladder cancer (5,7,11,59). Saccharin is approved for use in several countries. Its use is not permitted in Canada, and a health warning on the label of saccharin-containing foods is required in the United States (7,8,10). 

Sears MR, Taylor DR. The beta 2-agonist controversy. Observations, explanations and relationship to asthma epidemiology. Drug Saf 1994 ll(4) 259-83. 

Despite the powerful nature of biomonitoring (Wilhelm et al. 2004), the utility and interpretation of the data are controversial. The controversy stems in part from the fact that the pace at which biomonitoring data are being generated has eclipsed the development of basic epidemiology, toxicology, and exposure-assessment techniques that are needed to evaluate... 

SILBERGELD, E.K. (1988). Epidemiology versus risk assessment Resolving some old controversies, Risk Anal. 8, 555-557. 

There has been some epidemiological confirmation of the probability of a significant death rate. A law passed in Texas in the early 1990s required the reporting of death within 2 weeks after ECT. From June 1993 through August 1994, 8 deaths were reported among nearly 1,700 patients subjected to shock treatment. Controversy surrounds causation, and critics of ECT attempted without success to obtain more autopsy details (Smith, 1995). 

Huncharek M. 1994. Asbestos and cancer Epidemiological and public health controversies. Cancer Invest 12(2) 214-222. 

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