Eosinophils history

Pustular drug eruptions due to penicillin (195), amoxicillin (196), ampicillin (197), bacampicillin (198), cefazo-hn (199,200), cefradine (201), cefalexin (202), cefaclor (203), or imipenem -I- cilastin (204) seem to form a distinct chnical entity that has to be differentiated from pustular psoriasis, which can be drug-induced as well (204). A history of drug exposure, rapid disappearance of the eruption after the drug is stopped, and eosinophils in the inflammatory infiltrate argue in favor of pustular drug eruptions. 

A 55-year-old non-alcoholic obese woman, who was allergic to sulfa drugs, presented with a 5-day history of jaundice, malaise, and a pruritic rash that began 3 weeks after she started to take celecoxib 200 mg/day for radicular pain (7). There were marked increases in liver enzymes and bilirubin and a peripheral eosinophi-lia. Liver biopsy showed marked intrahepatocyte cholestasis with eosinophil-rich inflammation, consistent with a drug reaction. Her symptoms and laboratory abnormalities completely resolved after withdrawal of celecoxib but took a long time (4 months) to normalize. 

A 33-year-old man with a 3-year history of Crohn s disease had previously received a weU-tolerated single infusion of infliximab. When, 14 months later, he received a second infusion for exacerbation of the disease he had no immediate adverse effects, but complained of myalgia, arthralgia, nausea, and vomiting 7 days later and received diphenhydramine. After 3 days he had dyspnea, fever, and chills. An open lung biopsy showed features of eosinophilic pneumonia and no... 

A 23-year-old man with no previous history of digestive disorders took interferon alfa for chronic hepatitis C. After 2 weeks of treatment, he had severe abdominal pain and diarrhea. The absolute eosinophil count was... 

The effect of prenatal exposure on allergic sensitisation has been investigated. No correlation was found between cord blood IgE of newborns and an active smoking history of either mothers or fathers [271(111), 272(111)]. However, cord blood eosinophil counts were found to correlate with the urinary cotinine levels of mothers [273(Ila)]. 

Despite important contributions of research into the cause of AD, the complicated genetic, environmental, and immunologic mechanisms that produce AD are not completely understood. The hereditary component of AD s etiology is particularly strong, as children with one affected parent have a 60% likelihood of having an atopic disease. If both parents are afflicted, the child has an 80% chance of developing an atopic condition. Paternal AD and asthma are stronger contributors to this risk, in contrast to maternal history. Most patients with AD are found to have elevated eosinophils and serum... 

Almost all patients with eosinophilic gastroenteritis have a peripheral eosinophilia. A history of allergy can be obtained in half of the patients. The stomach can be solely involved, but more commonly the small bowel also participates in the disease process. If patients only have eosinophilic gastritis, they present with epigastric pain, nausea and vomiting or hematemesis and/or melena, while patients with eosinophilic enteritis will have diarrhea, malabsorption or a protein-losing enteropathy. 

Fig.26.19a,b. Chronic eosinophilic pneumonia in a 56-year-old man presenting with a 4-week history of cough and fever. Moderate blood eosinophilia is found in laboratory workup, a Axial CT image shows strikingly peripheral wedge-shaped airspace consolidations, b The upper lobe predominance of the consolidations is displayed on coronal CT image... 

A 56-year-old man with no known past medical history was treated for osteomyelitis with piperacillin/tazobac-tam for 6 weeks. After that day, he developed fever and a rash, and urinalysis revealed eosinophils 4—25%. He was switched to treatment with meropenem and developed worsening renal fxmction and rash. Meropenem was stopped and he was treated with 6 weeks of corticosteroids his renal function rehmied to baseline on hospital day 46. While several beta-lactam antibiotics have been implicated as the cause of AIN, this case showed a potential cross-sensitivity between piperacillin/tazobactam and meropenem [42 ]. 

Special fypes of HCC have disfincf hisfologic paf-ferns and nafural history fibrolamellar carcinoma, clear cell HCC and pedunculated HCC. Fibrolamellar carcinoma is composed of large eosinophilic cells arranged in fhin or fhick frabeculae fhaf are surrounded by fibrous bounds wifh lamellar sfranding... 

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