EOF receptor

Lin CR, Chen WS, Kruiger W et al. Expression cloning of human EOF receptor complementary DNA gene amplification and three related messenger RNA products in A431 ceWs. Science 1984 224 843-848. 

The role of Apo B containing lipoproteins other than LDL has been reviewed in ref. 411. pVLDL enhances iNOS expression and nitrite accumulation in IL-1 -stimulated VSMC (412). xi rat aortic SMC, remnant lipoproteins transactivate EOF receptor via PKC and the shedding of membrane-bound soluble heparin-binding EGF-like growth factor from SMCs, resulting in SMC proliferation (413). 

Treatment of NIH3T3 cells with 15 or 20 pM curcumin for 15 min inhibited TPA-induced PKC activity in particulate fraction by 26 or 60% and did not affect the level of PKC protein (32). Curcumin (10 pM) inhibits EOF receptor kinase activity up to 90% in a dose- and time-dependent manner and also Inhibits EGF-induced tyrosine phosphorylation of EGF-receptors in A431 cells (33). 

Schenk, S., Hintermann, E., BUban, M., et al. Binding to EOF receptor of a leuninin-5 EGF-Uke fragment liberated during MMP-dependent mammary gland involution. J. Cell Biol. 161, 197-209 (2003). doi 10.1083/jcb.200208145... 

Two peptides that have received attention for their potential role in barrier maintenance are epidermal growth factor (EOF) and transforming growth factor-alpha (TGF-alpha). EGF is secreted in saliva and from duodenal glands, while TGF-alpha is produced by gastric epithelial cells. Both peptides bind to a common receptor and stimulate epithelial ceh proliferation. In the stomach they also enhance mucus secretion and inhibit acid production. 

CE also has the ability of providing improved resolutions for similar structures, such as peptides, which may be difficult or impossible to separate by any and all HPLC methods (39). Because it moves analytes and the buffer by electroosmotic flow (EOF) rather than by pressurized flow delivery as in HPLC, individual peaks tend to be much narrower, sharper, symmetrical, and of higher plate counts (efficiency, N (number of theoretical plates or plate count for peak)). This also leads to improved resolutions of nearly identical compounds, assuming that they have some differences in mass-to-charge ratios or can interact with buffer components differently, as with their ligands or receptors. 

In 1995, a report using ACE-MS was published (87). Chu et al. reported on the development of a simple, one-step procedure for the on-line separation and identification of ligands that again bind most tightly to a receptor. Vancomycin was again chosen as the receptor, and it was used in the electrophoretic buffer to completely fill the capillary. In order to prevent vancomycin from flowing into the MS, the electrophoretic buffer pH was chosen to prevent the vancomycin from migrating. A neutral, hydrophilic, polymer-coated capillary was used to minimize EOF in the capillary and to therefore reduce the vanco-... 

Receptor models can also be used together with spatial distribution of measurements to estimate the spatial distribution of emission fluxes. The empirical orthogonal function (EOF) method is one of the most popular models for this. Henry et al. (1991) improved the EOF method by using wind direction in addition to spatially distributed concentration measurements as input. We describe this approach below. 

Standing of source-receptor relationships for nonreactive species in an airshed. The.se methods include the chemical mass balance (CMB) used for. source apportionment, the principal component analysis (PCA) used for source identification, and the empirical orthogonal function (EOF) method used for identification of the location and strengths of emission sources. A detailed review of all the variations of these basic methods is outside the scope of this book. For more information the reader is referred to treatments by Watson (1984), Henry et al. (1984), Cooper and Watson (1980), Watson et al. (1981), Macias and Hopke <1981), Dattner and Hopke (1982), Pace (1986), Watson et al. (1989), Gordon (1980, 1988), Stevens and Pace (1984), Hopke (1985, 1991), and Javitz et al. (1988). 

APIFVXT Cadheiin EOF LAG seven-pass G-type receptor 2 (163-201) NA NT... 

Mouse epidermal growth factor (EOF) is a relatively small protein consisting of 53 amino acids with three disulfide bonds. EGF can be described as a right-handed mitten where the thumb and palm represent separate domains and the hollow is postulated as the site where the EGF receptor binds. Ikura and Go have carried out a normal mode analysis of this protein. As was the case with lysozyme, the lowest frequency mode (4.1 cm" ) corresponds to a hinge-bending motion. This finding helps to rationalize the difference between two NMR structures which have been solved for this molecule. These two structures differed in terms of the distance between the two domains, due to the paucity of interdomain NOEs. Normal modes have also been incorporated into the structure determination process, as described in Sections 3.4 and 3.5. 

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