Enzymatic catalysis implications

Alper, K. O., Singla, M., Stone, J. L., Bagdassarian, C. K. (2001). Correlated corrforma-tional fluctuations during enzymatic catalysis Implications for catalytic rate enhancement. Prote/w /. 10,1319-1330. 

Results of a study of electrostatic acceleration of enolization in cationic ketones have implications for enzymatic catalysis of enolization.136 Rate constants determined for water-, acetate- and hydroxide ion-catalysed enolizations of cationic ketones (79) (pK 11.13) and (80) (pK 11.90) have been compared with those for (81). It has been estimated that the inductive effects of the charged lings lower the p/y,s of (81) and (79) by 4.2 and 1.2 log units, respectively, whereas for (79) the electrostatic effect lowers the pAa by 6.3 log units, and enhances oh by 330-fold relative to a typical methyl ketone. The rate of enolization of (81) is enhanced 2.3 x 104-fold by the through-space electrostatic effect. 

Discuss the implications of Pauling s 1948 statement that Enzymes are molecules that are complementary in structure to the transition states of the reactions they catalyse. Include in your answer a discussion of the selectivity of enzymatic catalysis. 

Methyl Transfer Reactions. Implications for the Concept of Enzymatic Catalysis via Transition State Compression. 

What are the possible functional implications of such gating motions Ensuring the maximum possible speed of binding is clearly one function. For example, it is necessary to create a special environment around a substrate for enzymatic catalysis, but evolutionary pressure has forced the creation of this environment to happen very rapidly for certain enzymes. 

Moiseyev, N., Rucker, J., Glickman, M. H. (1997) Reduction of ferric iron could drive hydrogen tunneling in lipoxygenase catalysis Implications for enzymatic and chemical mechanisms, J. Am. Chem. Soc. 119, 3853-3860. 

P. Geerlings, A Computational and Conceptual DFT Study of the Reactivity of Anionic Compounds Implications for Enzymatic Catalysis,/. Phys. Chem. A, 2003, 107, 6828-6836. 

Shan, S., Loh, S, and Herschlag, D. "The Energetics of Hydrogen Bonds in Model Systems Implications For Enzymatic Catalysis." Science, 272,97-101 (1996). 

Hcrschlag, D., and Admiraal, S. J. "Mapping the Transition State for ATP Hydrolysis Implications for Enzymatic Catalysis." Ciirr. Biol., 2,729-739 (1995). 

S. Shan, S. Loh and D. Herschlag, The energetics of hydrogen bonds in model systems Implications for enzymatic catalysis. Science, 272 (1996) 97. 

Ross, G., Loverix, S., De Proft, F., Wyns, L., Geerlings, P. (2003). A computational and conceptual DFT study of the reactivity of anionic compounds implications for enzymatic catalysis. J. Phys. Chem. A 107, 6828-6836. 

Bacteria have been Implicated in the formation of N-nitroso compounds under a wide variety of conditions representing both vitro and vivo situations Mechanisms of participation and/or catalysis Include a) decrease of the pH of the system, b) reduction of nitrate to nitrite, c) adsorption of amine onto the cell surface or cytoplasmic membrane, d) actual enzymatic formation. The literature of the field will be reviewed and experimental evidence which tests the above mechanisms will be presented ... 

Catalysis, enzymatic, physical organic model systems and the problem of, 11,1 Catalysis, general base and nucleophilic, of ester hydrolysis and related reactions, 5,237 Catalysis, micellar, in organic reactions kinetic and mechanistic implications, 8,271 Catalysis, phase-transfer by quaternary ammonium salts, 15,267 Catalytic antibodies, 31,249... 

---