Environmental Protection Agency High Production Volume

U.S. Environmental Protection Agency, High Production Volume (HPV) Challenge Program, http //www.epa.gov/hpv/. 

Solvents are ubiquitous in the workplace and are produced in the millions of kilograms annually. They also appear in many household products such as cleaners, glues, and paint thinners. Because so many workers are exposed to solvents, and because their use is so common in other settings, the US Environmental Protection Agency (EPA) proposed that solvent manufacturers undertake a comprehensive evaluation of ten solvents with high production volumes. They specified four components in the evaluation functional observation battery, motor activity, neuropathology, and schedule-controlled operant behavior. 

U.S. EPA (U.S. Environmental Protection Agency), What Do We Really Know about the Safety of High Production Volume (HPV) Chemicals, United States Environmental Protection Agency, Office of Pollution Prevention and Toxics, Washington, DC, 1998a. 

United States Environmental Protection Agency. Office of Pesticides and Toxic Substances, Existing Chemicals Assessment Division. Information packet on the OECD Screening Information Data Set (SIDS) Program for high production volume (HPV) chemicals, 1992. 

Environmental Protection Agency, 40 CFR, Part 799, testing of certain High Production Volume Chemicals, pp. 1-51, March 2001. 

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