Environmental cell responses

Heo Y, Lee WT, Lawrence DA. 1997. In vivo the environmental pollutants lead and mercury induce oligoclonal T cell responses skewed toward type-2 reactivities. Cell Immunol 179 185-195. 

Interestingly and consistent with previously reported results for prenatal TCDD exposure (another environmental contaminant found to be released as a result of the terrorist attack on the WTC) the effects on the aforementioned AMPA-mediated single cell responses were validated by RT-PCR. Glutamate receptor, AMPA-type subunit (GluRl) temporal developmental mRNA expression was determined in control and B(a)P-exposed offspring. The results shown in Figure 17.8 were normalized to ISsRNA expression. The results presented in this pre-weaning developmental... 

Prescott SL, Macaubas C, Holt BJ, Smallacombe T, Loh R, Sly PD, Holt PG Transplacental priming of the human immune system to environmental allergens Universal skewing of initial T-cell responses towards the Th-2 cytokine profile. Immunol J 1998 160 4730-4737. 

Human cell response to environmental organic toxins. Holman et al. (2000) have investigated the changes in intracellular phosphate and lipid concentrations in human cells as a function of exposure to polychlorinated hydrocarbons and compared their findings to quantitative results from reverse transcription polymerase chain reaction (RT-PCR). The human cells were exposed to low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a potent and well-studied man-made toxin. TCDD causes harmful effects at exposure levels of hundreds to thousands of times lower doses than most chemicals of environmental concern. This polychlorinated hydrocarbon causes an increase in the production of the cytochrome P4501A1 (CYP1A1) gene, which can be monitored with RT-PCR. 

Tools to Study Cell Responses to Environmental Heterogeneities... 

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