Endoplasmic reticulum-associated degradation ERAD

McCracken, A. A. and Brodsky, J. L. Evolving questions and paradigm shifts in endoplasmic-reticulum-associated degradation (ERAD). Bioessays 2003, 25, 868—77. 

Embden-Meyerhof-Parnas pathway 650 photobioreactors 589,628 endoplasmic reticulum (ER) 648, 701 endoplasmic reticulum associated degradation (ERAD) 701 enzymes 677,703... 

Yamaski, S., Yagishita, N Tsuchimochi, K Nishioka, K., and Nakajima, T, Rheumatoid arthritis as a hyper-endoplasmic reticulum-associated degradation disease, Arthritis Res. Ther. 7, 181-186, 2005 Meusser, B., Hirsch, C Jarosch, E and Sommer, T., ERAD the long road to destruction. Nature Cell Biol. 7, 766-772, 2005. 

Abbreviations CBE conduritol B-epoxide CSF cerebrospinal fluide CMT chaperon-mediated therapy CNS central nervous system ER endoplasmic reticulum ERAD endoplasmic reticulum associated degradation ERT ... 

The UPS also plays a major role in protein quality control. In a process known as endoplasmic associated degradation (ERAD), misfolded proteins, which are formed in the endoplasmatic reticulum, are translocated back to the cytoplasm and degraded by the proteasome. 

Fig. 12.3 The unfolded proteins in the endoplasmic reticulum turn on the unfolded protein response (UPR) and ER-associated degradation (ERAD). The presented model was adapted from McCracken and Brodsky [59]...

ERAD Endoplasmic reticulum-associated protein degradation... 

Chaperones. Figure 2 The multiple roles of BiP in the biogenesis of the secretory proteins. BiP, immunoglobulin heavy chain binding protein ER, endoplasmic reticulum ERAD, ER-associated degradation ERj, resident ER protein with J-domain Sec61, core subunit of the protein translocase UPR, unfolded protein response that involves several signal transduction pathways that are activated in order to increase the biosynthetic capacity and decrease the biosynthetic burden of the ER... 

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