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Endocannabinoids pharmacology

Di Marzo V, A brief history of cannabinoid and endocannabinoid pharmacology as inspired by the work of British scientists. Trends Pharmacol Sci 27 134-140, 2006. [Pg.45]

Endocannabinoid Pharmacological Actions Some Major Differences... [Pg.147]

To clone the novel receptors proposed for AEA and to establish their actual participation in endocannabinoid pharmacological actions in vivo... [Pg.172]

Endocannabinoids. Table 1 Changes of endocannabinoid levels during pathological conditions and subsequent possible pharmacological interventions... [Pg.467]

Based on the role of endocannabinoids and cannabinoid receptors in several pathological conditions, the pharmacological manipulation of their levels or action is being developed as a therapeutic strategy. Enhancement of endocannabinoid signalling when this plays uniquely a protective role can be effected in a safer way using (i) cannabis extracts in which the presence of non-psychotropic cannabinoids with therapeutic activity per... [Pg.468]

All the foregoing pharmacological effects of anandamide, in conjunction with the well-documented existence of specific systems for its biosynthesis, catabolism, and cellular reuptake to be discussed shortly, suggest that anandamide is indeed the endogenous cannabinoid ligand. The other two less studied A -acylethanolamide endocannabinoids and also 2-AG may serve similar functions. The differential roles of each of these four endocannabinoids are still unclear. [Pg.104]

Porter, A.C. and Felder, C.C. (2001) The endocannabinoid nervous system unique opportunities for therapeutic intervention. Pharmacology el Therapeutics, 90 (1), 45—60. [Pg.277]

Mechoulam R, Fride E and Di Marzo V (1998). Endocannabinoids. European Journal of Pharmacology, 359, 1-18. [Pg.274]

Piomelli D, Giuffrida A, Calignano A and de Fonseca FR (2000) The endocannabinoid system as a target for therapeutic drugs. Trends in Pharmacological Sciences 21, 218-224. [Pg.119]

Moreira, F. A., Kaiser, N., Monory, K., and Lutz, B. (2008). Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty add amide hydrolase (FAAH) is mediated by CB1 receptors. Neuropharmacology 54, 141-150. [Pg.70]

Di Marzo V, Breivogel CS, Tao Q, Bridgen DT, Razdan RK, Zimmer AM, Zimmer A, Martin BR (2000b) Levels, metabolism, and pharmacological activity of anandamide in CBi cannabi-noid receptor knockout mice. Evidence for non-CBi, non-CBi receptor-mediated actions of anandamide in mouse brain. J Neurochem 75 2434-2444 Di Marzo V, Melck D, Bisogno T, De Petrocellis L (1998) Endocannabinoids endogenous cannabinoid receptor hgands with neuromodulatory action. Trends Neurosci 21 521-528 Dickinson T, Fleetwood-Walker SM (1999) VIP and PACAP very important in pain Trends Pharmacol Sci 20 324-329... [Pg.494]


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See also in sourсe #XX -- [ Pg.164 , Pg.165 , Pg.166 , Pg.167 ]




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Endocannabinoid

Endocannabinoids

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