Embryo cells transgenic mouse production

The production of transgenic animals carrying rDNA in their genome arose from a combination of advances in embryology [239], understanding the differentiation of stem cells [240] in the developing embryo, and development of viral vectors [241]. This has had a broad range of applications, from production of knockout mice for fundamental research to animal models for human disease (e.g., a mouse model for HCV infections [242]). 

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