Electrophile-Responsive Element

Kong AN, Owuor E, Yu R, Hebbar V, Chen C, Hu R and Mandlekar S. 2001. Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE). Drug Metab Rev 33(3-4) 255-271. 

Kluth D, Banning A, Paur I, Blomhoff R, Brigelius-Flohe R. 2007. Modulation of pregnane X receptor- and electrophile responsive element-mediated gene expression by dietary polyphenolic compounds. Free Radic Biol Med 42 315-325. 

Friling RS, Bergelson S, Daniel V. 1992. Two adjacent AP-l-like binding sites form the electrophile-responsive element of the murine glutathione S-transferase Ya subunit gene. Proc Natl Acad Sci USA 89 668-672. 

Minsavage, G.D., Dillman, J.F. (2007). Bifunctional alkylating agent-induced p53 and nonclassical nuclear factor kappaB responses and cell death are altered by caffeic acid phenethyl ester a potential role for antioxidant/electrophilic response-element signaling. J. Pharmacol. Exp. Ther. 321 202-12. 

Moinova HR, Mulcahy RT. 1998. An electrophile responsive element (EpRE) regulates /3-naphthoflavone induction of the human y-glutamylcysteine synthetase regulatory subunit gene. J. Biol. Chem. 273 14683-89... 

Friling RS, Bensimon A, Tichauer Y, Daniel V. 1990. Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element. Proc. Natl. Acad. Sci. USA 87 6258-62... 

Moran JA, Dahl ER, Mulcahy RT. 2002. Differential induction of maJF, maJG and maJKexpression by electrophile-response element activators. Biochem. J. 361 371— 77... 

Zhu, M. and W.E. Fahl. Functional characterization of transcription regulators that interact with the electrophile response element. Biochem. Biophys. Res. Commun. 289 212-219, 2001. 

The up-regulation of GCS subunits by oxidative stress is mediated by different transcription factors such as nuclear factor kappa B (NF-kB), Sp-1, activator protein-1 (AP-1), activator protein-2 (AP-2) and antioxidant response elements (ARE) or electrophile responsive elements (EpRE). 

Zhang J, Hosoya T, Maruyama A, Nishikawa K, Maher JM, Ohta T, Motohashi H, Fukamizu A, Shibahara S, Itoh K, Yamamoto M (2007b) Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes. Biochem J 404 459-466 Zhu M, Fahl WE (2001) Functional characterization of transcription regulators that interact with the electrophile response element. Biochem Biophys Res Commun 289 212-219 Zipper LM, Mulcahy RT (2002) The Keapl BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm. J Biol Chem 277 36544-36552... 

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