Antioxidant/electrophile response element

Minsavage, G.D., Dillman, J.F. (2007). Bifunctional alkylating agent-induced p53 and nonclassical nuclear factor kappaB responses and cell death are altered by caffeic acid phenethyl ester a potential role for antioxidant/electrophilic response-element signaling. J. Pharmacol. Exp. Ther. 321 202-12. 

Holderman MT, Miller KP, Ramos KS Aetivation of nuclear protein binding to the antioxidant/electrophile response element in vaseular smooth muscle cells by benzo(a)pyrene. Biochem Biophys Res Commun 2000, 267 12-16. 

Miller KP, Chen YH, Hastings VL, Bral CM, Ramos KS Profiles of antioxidant/electrophile response element (ARE/EpRE) nuclear protein binding and c-Ha-ras transactivation in vascular smooth muscle cells treated with oxidative metabolites of benzo[a]pyrene. Biochem Pharmacol 2000, 60 1285-1296,... 

Miller KP, Ramos KS DNA sequence determinants of nuclear protein binding to the c-Ha-ras antioxidant/electrophile response element in vascular smooth muscle cells identification of Nrf2 and heat shock protein 90 beta as heterocomplex components. Cell Stress Chaperones 1005, 10 114-125. 

Kong AN, Owuor E, Yu R, Hebbar V, Chen C, Hu R and Mandlekar S. 2001. Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE). Drug Metab Rev 33(3-4) 255-271. 

The up-regulation of GCS subunits by oxidative stress is mediated by different transcription factors such as nuclear factor kappa B (NF-kB), Sp-1, activator protein-1 (AP-1), activator protein-2 (AP-2) and antioxidant response elements (ARE) or electrophile responsive elements (EpRE). 

Prestera T, Talalay P, Alam J, Ahn Yl, Lee PJ, Choi AM. Parallel induction of heme oxygenase-i and chemoprotective phase 2 enzymes by electrophiles and antioxidants regulation by upstream antioxidant-responsive elements (ARE). Mol Med 1995 1 827-837. 

Kim YC, Yamaguchi Y, Kondo N, Masutani H, Yodoi J (2003) Thioredoxin-dependent redox regulation of the antioxidant responsive element (ARE) in electrophile response. Oncogene 22 1860-1865... 

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