Elastin factors

Have specific interactions with collagen, elastin, fibronectin, laminin, and other proteins such as growth factors... 

Abstract Synthetic polymers and biopolymers are extensively used within the field of tissue engineering. Some common examples of these materials include polylactic acid, polyglycolic acid, collagen, elastin, and various forms of polysaccharides. In terms of application, these materials are primarily used in the construction of scaffolds that aid in the local delivery of cells and growth factors, and in many cases fulfill a mechanical role in supporting physiologic loads that would otherwise be supported by a healthy tissue. In this review we will examine the development of scaffolds derived from biopolymers and their use with various cell types in the context of tissue engineering the nucleus pulposus of the intervertebral disc. 

R. P. (1995). Bovine latent transforming growth factor /11-binding protein-2 Molecular cloning, identification of tissue isoforms, and immunolocalization to elastin-associated microfibrils. Mol. Cell. Biol. 15, 6932-6942. 

Carreras, I., Rich, C. B., Panchenko, M. P., and Foster, J. A. (2002). Basic fibroblast growth factor decreases elastin gene transcription in aortic smooth muscle cells. / Cell. Biochem. 85, 592—600. 

Kahari, V. M., Chen, Y. Q., Bashir, M. M., Rosenbloom, J., and Uitto, J. (1992). Tumor necrosis factor-alpha down-regulates human elastin gene expression. Evidence for the role of AP-1 in the suppression of promoter activity. J. Biol. Chem. 267, 26134-26141. 

These serine proteases are used to remove pathogens by their hydrolytic activity. They degrade cell membrane proteins and connective tissue matrices by hydrolysis of extracellular matrix proteins such as fibronectin, type IV collagen and laminin, or solubilizing fibrous elastins [55, 56]. Immune cell proteases also are capable of cleaving cytokines, growth hormone, neuropeptides, and procoagulant proteins such as Factors X and V. 

With respect to factors that cause stimulation of elastin synthesis in tissues, there is some evidence to suggest that... 

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