Eight-Membered Ring Preserved Substitution at Nitrogen, Sulfur, and Carbon

Liu and co-workers treated the (V,N -bis(trimethylsilyl) derivatives of 104 with 2,3,5-tris-O-benzoyl-D-ribosyl bromide. Debenzoylation of the intermediate product afforded /J-D-ribofuranosyl-/V,/V -pentameth-yleneurea nucleoside 137, found to be a cytidine deaminase (CDA) inhibitor against mouse kidney enzyme (although less effective than the seven- or six-membered ring homologs) (81JMC662). 

Reaction of isocyanates with diazocines 106 (R = H) afforded amidi-noureas 141 (R = Me, Et). These compounds, along with others that have 2,6-disubstituted benzene residues, evinced pharmacological activity 

Treatment of a mixture of 2,6-di-/m-butylphenol and trimethylamine with a product prepared in situ from 104 and oxalyl chloride in acetonitrile gave quinonemethide 144 (84CZP212600). 2,6-Dichlorophenylamino- 

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