Effect on infectivity

Antibiotics have demonstrated a well-known effect on infected skin. They should be carefully used prophylactically since they might enhance resistance rates of bacteria against common antibiotics. In case of infected or superinfected wounds they do help to recover the skin condition and are part in a successful management of AD. 

Contradictory reports continue to be published. An article in Infection Immunity (June 1985)9 concluded that peroxide infusions in rabbits didn t have any effect on infection. Hydrogen peroxide doesn t work at all to protect the heart of rats. In fact, it does more harm than good. (But who cares )... 

Preliminary work using loblolly pine seedlings growing in sand, explored the effect of simulated acid rain on the infection of roots by ectomycorrhizae. Shafer et al. ( ) found that simulated acid rain of pH 4.0 and 3.2 was inhibiting ectomycorrhizal infection when compared to roots exposed to pH 5.6. At pH 2.4 there appeared to be stimulatory effects on infection. The authors suggested that increased soil acidity was the cause of the enhanced ectomycorrhizal infection, as other experiments have shown that, if substrate acidity is increased, so will infection. The authors did caution, however, that this short term greenhouse study was just preliminary. 

According to the main strategies of anti-HIV gene therapy, two types of anti-viral genes are used. First, toxic genes that produce a lethal effect on infected cells are... 

Phagocytosis stimulating effect (polymorph Ieui >cyte8, macrophages) Stenulation of the phagocytosis in mice Protective effect on Infection in Mice (phagoqftosis)... 

Lyons A, Kelly JL, Rodick ML, et al. Major injury induces increased production of interleukin-iO by cell of the immune system with a negative effect on infection resistance. Ann Surgery 1997 226 450-460. 

Unfortunately, 2-deoxy-2,3-dehydrosialic acids have only medium potency. A number of analogs were synthesized and the most potent of them was the tri-fluoracetyl derivative exhibiting a potency of 0.8 pM. It was not active enough to show any beneficial effects on infected animals. 

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