Effect of Childhood Diseases

The spectrum of diseases that occur in the pediatric population is also quite different than diseases that afflict adults, and the effect of pediatric diseases 

FIGURE 23.15 Comparison of hepatic and renal clearance of selected drugs in children with cystic fibrosis ofen hats) and in controls solid hats). Clearance is enhanced in patients with cystic fibrosis. (Data from Rey Eet al. Clin Pharmacokinet 1998 35 313-29.) 

The Pediatric Pharmacology Research Unit (PPRU) is a network of experienced clinical investigators committed to facilitating pharmacological research in the pediatric medical community (55). Acting as a consortium, the PPRU has the potential to provide access to 

Lietman PS. Chloramphenicol and the neonate-1979 view. Clin Perinatol 1979 6 151-62. 

Burns LE, Hodgman JE, Cass AB. Fatal circulatory collapse in premature infants receiving chloramphenicol. N Engl J Med 1959 261 1318-21. 

---