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Echinocandin lipopeptides

M Tomishima, H Ohki, A Yamada, El Takasugi, K Maki, S Tawara, El Tanaka. FK463, a novel water-soluble echinocandin lipopeptide synthesis and antifungal activity. J Antibiot 52 674-676, 1999. [Pg.243]

CYCLIC LIPOPEPTIDES FROM FUNGAL METABOLITES 2.1 Echinocandin lipopeptides... [Pg.727]

Balkovec, J.M., Black, R.M., Hammond, M.L., etal. (1992) Synthesis, stability, and biological evaluation of water-soluble prodrugs of a new echinocandin lipopeptide. Discovery of a potential clinical agent for the treatment of systemic candidiasis and Pneumocystis carinii pneumonia (PCP). J. Med. Chem. 35 194-198. [Pg.630]

Figure I Representatives of the six naturally occurring families of echinocandin lipopeptide antifungal agents. Figure I Representatives of the six naturally occurring families of echinocandin lipopeptide antifungal agents.
Groll, A.H. Miokiene, D. Petraitis, V. Petraitiene, R. Ibrahim, K.H. Piscitelli, S.C. Bekersky, I. Walsh, T.J. Compartmental pharmacokinetics and tissue distribution of the antifungal echinocandin lipopeptide micafungin (FK463) in rabbits, Antimicrob.Agents Chemother., 2001, 45, 3322-3327. [Pg.396]

FR901379 - echinocandin-like lipopeptide with antifungal property... [Pg.25]

Echinocandins B-D -lipopeptide antibiotics and other peptides including aculeacin A, mulundocandin, and pneumocandins... [Pg.54]

Anidulafimgin (23 Echinocandin B (24) Lipopeptide Semi-synthetic Microbial Antifungal Inhibits fungal cell wall 279-293... [Pg.23]

Pharmacology Micafungin is a semisynthetic lipopeptide (echinocandin) synthesized by a chemical modification of a fermentation product of Coleophoma empetri F-11899. Micafungin inhibits the synthesis of 1,3- -D-glucan, an essential component of fungal cell walls, which is not present in mammalian cells. Pharmacokinetics ... [Pg.1695]

M Debono, BJ Abbott, JR Turner, LC Howard, RS Gordee, AS Hunt, M Barnhart, RM Molloy, KE Willard, DS Fukuda, TF Butler, DJ Zeckner. Synthesis and evaluation of LY121019, a member of a series of semisynthetic analogues of the antifungal lipopeptide echinocandin B. Ann NY Acad Sci 544 152-167, 1988. [Pg.243]

Initial modification of the acyl side chain yielded FR131535.11 The synthesis of this novel echinocandin-like lipopeptide is outlined in Figure 15.5. The palmitoyl group was removed from FR901379 by treating it with acylase from Actinoplanes utahensis, which yielded FR179642. A new acyl side chain was prepared starting with 1-bromooctane and 4-hydroxybenzoic acid. [Pg.418]

The fungal metabolite echinocandin B (118)is one of the lipopeptides, in which a cyclic hexapeptide is combined with a long-chain fatty acid. Echinocandin B inhibits jS-l,3-glu-can synthesis and as a result has anti-Candida and anti-Pneumocystis carimi activity (149). As a group, the echinocandins are not orally bioavailable, are haemolytic, and are not very... [Pg.877]

Synthesis of the cyclic hexapeptide echinocandin D (256) involves a key intermediate tetrapeptide 255 which is prepared from 253 and AMinoleyl-N-Boc ornithine (254) using DEPC.95 Echinocandin D, isolated from Aspergillus ruglosus, is a member of a family of lipopeptides possessing high antifungal activity. [Pg.538]

Pneumocandins and echinocandins compose a new class of cyclic lipopeptide antifungal compounds [38]. Echinocandin B, 9, inhibits 1,3-P-D-glucan synthase in C. albicans, a critical enzyme in the production of cell well components. Two semi-synthetic derivatives have entered clinical trials. Merck s L-724,872 has been well tolerated in phase I clinical studies and is currently in phase II trials in patients with HIV and candidiasis. However, it is not absorbed orally and must be delivered intravenously. Lilly s LY303366 is also currently in clinical trials with people with HIV and candidiasis. These compounds appear to have fungicidal activity yet are not as toxic as Amphotericin B [21,29, 30]. [Pg.62]

Tricyclic spiroketal glycosides from cultures of Pa-pularia sphaerosperma. The P, have antibiotic activities. Similar to the lipopeptide antibiotic echinocandin B, they inhibit the biosynthesis of /S- glucans in yeasts. [Pg.464]

Caspofungin acetate for injection Semisynthetic lipopeptide (echinocandin) compound synthesized from a fermentation product of Glarea lozoyensis. Antifungal medicine used to treat serious fungal infections in adults and children [266]... [Pg.1400]

See other pages where Echinocandin lipopeptides is mentioned: [Pg.317]    [Pg.317]    [Pg.134]    [Pg.601]    [Pg.313]    [Pg.230]    [Pg.243]    [Pg.426]    [Pg.431]    [Pg.431]    [Pg.432]    [Pg.437]    [Pg.455]    [Pg.465]    [Pg.466]    [Pg.413]    [Pg.414]    [Pg.414]    [Pg.1464]    [Pg.7]    [Pg.1197]    [Pg.248]    [Pg.37]    [Pg.1733]    [Pg.113]    [Pg.188]    [Pg.217]    [Pg.316]    [Pg.297]   
See also in sourсe #XX -- [ Pg.727 ]



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