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Echinocandin antifungal lipopeptide

FR901379 - echinocandin-like lipopeptide with antifungal property... [Pg.25]

M Debono, BJ Abbott, JR Turner, LC Howard, RS Gordee, AS Hunt, M Barnhart, RM Molloy, KE Willard, DS Fukuda, TF Butler, DJ Zeckner. Synthesis and evaluation of LY121019, a member of a series of semisynthetic analogues of the antifungal lipopeptide echinocandin B. Ann NY Acad Sci 544 152-167, 1988. [Pg.243]

Anidulafimgin (23 Echinocandin B (24) Lipopeptide Semi-synthetic Microbial Antifungal Inhibits fungal cell wall 279-293... [Pg.23]

M Tomishima, H Ohki, A Yamada, El Takasugi, K Maki, S Tawara, El Tanaka. FK463, a novel water-soluble echinocandin lipopeptide synthesis and antifungal activity. J Antibiot 52 674-676, 1999. [Pg.243]

Synthesis of the cyclic hexapeptide echinocandin D (256) involves a key intermediate tetrapeptide 255 which is prepared from 253 and AMinoleyl-N-Boc ornithine (254) using DEPC.95 Echinocandin D, isolated from Aspergillus ruglosus, is a member of a family of lipopeptides possessing high antifungal activity. [Pg.538]

Pneumocandins and echinocandins compose a new class of cyclic lipopeptide antifungal compounds [38]. Echinocandin B, 9, inhibits 1,3-P-D-glucan synthase in C. albicans, a critical enzyme in the production of cell well components. Two semi-synthetic derivatives have entered clinical trials. Merck s L-724,872 has been well tolerated in phase I clinical studies and is currently in phase II trials in patients with HIV and candidiasis. However, it is not absorbed orally and must be delivered intravenously. Lilly s LY303366 is also currently in clinical trials with people with HIV and candidiasis. These compounds appear to have fungicidal activity yet are not as toxic as Amphotericin B [21,29, 30]. [Pg.62]

Caspofungin acetate for injection Semisynthetic lipopeptide (echinocandin) compound synthesized from a fermentation product of Glarea lozoyensis. Antifungal medicine used to treat serious fungal infections in adults and children [266]... [Pg.1400]

Figure I Representatives of the six naturally occurring families of echinocandin lipopeptide antifungal agents. Figure I Representatives of the six naturally occurring families of echinocandin lipopeptide antifungal agents.
Groll, A.H. Miokiene, D. Petraitis, V. Petraitiene, R. Ibrahim, K.H. Piscitelli, S.C. Bekersky, I. Walsh, T.J. Compartmental pharmacokinetics and tissue distribution of the antifungal echinocandin lipopeptide micafungin (FK463) in rabbits, Antimicrob.Agents Chemother., 2001, 45, 3322-3327. [Pg.396]

See other pages where Echinocandin antifungal lipopeptide is mentioned: [Pg.134]    [Pg.313]    [Pg.243]    [Pg.465]    [Pg.1197]    [Pg.601]    [Pg.426]    [Pg.437]    [Pg.455]    [Pg.1464]    [Pg.7]    [Pg.37]    [Pg.113]    [Pg.188]    [Pg.316]    [Pg.297]   
See also in sourсe #XX -- [ Pg.388 ]



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Echinocandins antifungals

Lipopeptide

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