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Coleophoma empetri

Pharmacology Micafungin is a semisynthetic lipopeptide (echinocandin) synthesized by a chemical modification of a fermentation product of Coleophoma empetri F-11899. Micafungin inhibits the synthesis of 1,3- -D-glucan, an essential component of fungal cell walls, which is not present in mammalian cells. Pharmacokinetics ... [Pg.1695]

Figure 15.4 Scanning electron micrograph of Coleophoma empetri F-11899. Figure 15.4 Scanning electron micrograph of Coleophoma empetri F-11899.
FR901379 (isolated from the fungus Coleophoma empetri) and echinocandin B (isolated from Aspergillus nidulans) led to two additional clinical agents of this class, micafungin (41) and anidulafungin (42), respectively. (16, 17)... [Pg.1465]

WFl 1899A, B and C (Fig.37) were discovered by Iwamoto et al. in 1994 as water-soluble antifungal compounds from Coleophoma empetri F-11899. These compounds contain a sulfate residue in their structure, while other natural-echinocandins do not. Replacement of the sulfate residue in WF11899A by an arylsulfate greatly diminishes its water solubility, indicating that its excellent water solubility is attributed to the sulfate residue ... [Pg.728]

See other pages where Coleophoma empetri is mentioned: [Pg.63]    [Pg.414]    [Pg.418]    [Pg.426]    [Pg.731]    [Pg.29]    [Pg.319]    [Pg.63]    [Pg.414]    [Pg.418]    [Pg.426]    [Pg.731]    [Pg.29]    [Pg.319]   
See also in sourсe #XX -- [ Pg.418 , Pg.419 , Pg.426 ]

See also in sourсe #XX -- [ Pg.728 , Pg.731 ]



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