Early-generation testing

For risk estimation, other mouse tests are appropriate. Dominant phenotypes (skeletal effects, possibly supplemented by cataracts) in mice provide the only current basis for assessing the early-generation phenotypic effects in man. These estimates must be regarded as very uncertain until there have been more comparative studies in mice and... 

The second issue of dispersants of importance is that of the toxicity of the dispersant and the toxicity of the dispersed oil droplets. Toxicity became a large issue in the early 1970s when application of toxic products resulted in substantial loss of sea life [6]. Subsequent generations of dispersants have had substantially less (often one hundredth) the toxic effect that early generations of dispersants had [6]. A standard measure of toxieity is the acute toxicity to standard species such as the rainbow trout. The LCso of a substance is the Lethal Concentration to 50% of a test population usually given in mg/L, nearly equivalent to parts per million. 

The test department develops a verification test plan. To shorten time to market, test development or even some testing starts early and is largely done in parallel with the development of the systems itself. As far as feasible, models are developed to automatically generate tests and test suites. Regression tests that are performed with a certain frequency are automated, too. This allows for a large part of the tests to be automated and run frequently. 

The project was constructed in 2001 and early 2002. Testing has commenced. As of this writing some 5,000 tonnes of sawdust has been burned at the Willow Island Generating Station. Cofiring was... 

Sulfonylureas. The hypoglycemic effect of sulfonylureas was first noted in the early 1940s when several patients died in hypoglycemic coma after testing glyprothia2ole, a synthetic sulfonamide used to treat typhoid. Chemical modifications which enhanced activity and lowered toxicity led to the development of the first-generation sulfonylureas. Carbutamide [339-43-5] the first commercial sulfonylurea, came onto the European... 

The first experimental breeder reactor (EBR-1), which was the first reactor to generate electricity on a practical basis, went into operation in 1951 at the National Reactor Testing Station in Idaho. After the first reactor was damaged by a power excursion, EBR-11 was put into operation in 1961 (57). As of early 1995 it continued to operate very well. 

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