E metabolism

P-450 (CYP) enzymes, specifically CYP3A. Parker et al (2000) found that ketoconozole, a selective inhibitor of CYP3A, inhibited the metabolism of y- and a-tocopherol in rat primary hepatocytes, whereas sulfaphenazole and cyclosporin (inhibitors of CYP2C and CYP27, respectively) did not. It was also significant that sesamin [see discussion of sesamolin in Section F, above] strongly inhibited tocopherol catabolism, which may account for why this lignan increases tissue tocopherol concentrations (Parker et al, 2000). 

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Suzuki, T. and Takahashi, E., Metabolism of methionine and biosynthesis of caffeine in tea plant, Biochemistry, 160,171,1976c. 

Shier, W.T., Koda, L.Y., and Bloom, F.E., Metabolism of pi I dopamine following intracerebroven-tricular injection in rats pretreated with ethanol or choral hydrate, Neuropharmacology, 22, 279, 1983. 

Johansen, S. S. Licht, D., and Arvin, E., Metabolic Pathways of Quinoline, Indole and Their Methylated Analogs by Desulfobacterium Indolicum (DSM 3383). Appl Microbiol Biot, 1997. 47(3) pp. 292-300. 

Schachter, H. (1972). The use of the steady-state assumption to derive kinetic formulations for the transport of a solute across a membrane. In Metabolic Transport, ed. Hokin, L. E., Metabolic Pathways. Vol. 6, Series ed. Greenberg, D. M., Academic Press, New York, pp. 1-15. 

Ahmed. M.K. and Casida, J.E. Metabolism of some organophosphorus insecticides by microorganisms, /. Econ. Entomol, 51(l) 59-63, 1958. 

Garner, W.Y. and Menzer, R.E. Metabolism of lV-hydrox3miethyl dimethoate and Wdesmethyl dimethoate in bean plants. Pestic. Blochem. Physiol., 25 218-232, 1986. 

Pillai, C.G.P., Weete, J.D., and Davis, D.E. Metabolism of atrazine by 5parfiina aiferarffora. 1. Chloroform-soluble metabolites,/. Agric. Food Chem., 25(4) 852-855, 1977. 

Pharmacokinetic Interactions. Remember that pharmacokinetics is the study of what the body does to the medication. This includes how the body transports, inactivates (i.e., metabolizes), and eliminates the medication. Sometimes, one medication can change the way the body handles another medication. This is known as a pharmacokinetic interaction. There are two types of pharmacokinetic interactions. One type occurs in the medication transportation system, and the other occurs in the medication elimination system. 

Elimination relates to the loss of a substance by the organism, i.e., metabolism and excretion combined. 

Using human physiology and in vitro data and clinically relevant input parameters (i.e., metabolic stability in human hepatocytes and microsomes as well as prothrombin time measured in various batches of human plasma) the model was extended to human. This human PK/PD model was then used to investigate the impact of the various physicochemical, pharmacokinetic and pharmacodynamic properties on the anticoagulant profile (i.e., prothrombin time) expected in man. 

E. Metabolism of His begins with oxidative deamination leading to production of free ammonia and the intermediate urocanic acid. 

Brearley, C.A. Hanke, D.E. Metabolic relations of inositol 3,4,5,6-tetrakis-phosphate revealed by cell permeabilization. Identification of inositol 3,4,5, 6-tetrakisphosphate 1-kinase and inositol 3,4,5,6-tetrakisphosphate phosphatase activities in mesophyll cells. Plant Physiol., 122, 1209-1216 (2000)... 

Rahouti, M. Seigle-Murandi, F., Steiman, R., Eriksson, K.E. Metabolism of ferulic acid by Paecilomyces variotii and Pestalotiapalmarum. Appl Env Microbiol 1989 55 2391-2398. 

Murphy, G.J.P., Briggs, p-E. "Metabolism of ent-kaurenpl-17 l C, ent-kaurenal-17- and ent-kaurenoic acid-17- C by germinating Hordeum distichon grains." Phytochemistry,... 

Se 50-200 /zg Glutathione peroxidase Associated with vitamin E metabolism may be considered to be a nonmetal... 

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