Dysidea polybrominated diphenyl ethers

Polybrominated diphenyl ethers from the Indonesian marine sponge Dysidea herbacea are active against the Gram-positive bacteria Bacillus subtilis (MIC 0.20 pg/ml) and the phytopathogenic fungus Cladosporium cucumerinum. Compounds 90 and 91 are also active in the brine shrimp lethality test (LC50 0.96 and 0.94 pg/ml) [81]. 

Handayani D, Edrada RA, Proksch P, Wray V, Witte L, Van Soest RWM, Kunzmann A, Soedarsono (1997) Four New Bioactive Polybrominated Diphenyl Ethers of the Sponge Dysidea herbacea from West Sumatra, Indonesia. J Nat Prod 60 1313... 

The polybrominated diphenyl ether derivatives have also been reported to inhibit enzymes implicated in tumor development and artherosclerotic plague which indicates their potential as promising candidates for therapeutic agents [186]. It was previously shown that the symbiotic cyanobacterium, Oscillatoria spongeliae produces the polybrominated diphenyl ether [187, 188]. The marine sponge Dysidea herbacea collected from Indonesia, yielded a series of polybrominated diphenyl ether congeners [189, 190]. D. herbacea occurs in two chemotypes [188] - one chemotype contains both polychlorinated amino acid derivatives [191, 192] and sesquiterpenes [193, 194], while the second chemotype contains... 

Fig. (16). Polybrominated diphenyl ethers from Dysidea herbacea.

Carte, B., and D.J. Faulkner Polybrominated Diphenyl Ethers from Dysidea herbacea, Dysidea chlorea and Phyllospongia foliascens. Tetrahedron 37, 2335 (1981). 

Handayani, D., Edrada, R.A., Proksch, P., Wray, V., Witte, L., Van Soest, R.W.M., Kunzmann, A., and Soedarsono (1997) Four new bioactive polybrominated diphenyl ethers of the sponge Dysidea... 

Xu, Y,-M., Johnson, R.K., and Hecht, S.M. (2005) Polybrominated diphenyl ethers from a sponge of the Dysidea genus that inhibits Tie2 kinase. Bioorg. Med. Chem., 13, 657-659. 

Zhang, H., Sldldum, A., Stromquist, E., Rose-Hellekant, T, and Chang, L.C. (2008b) Bioactive polybrominated diphenyl ethers from the marine sponge Dysidea sp. J. Nat. Prod., 71, 262-264. 

Fu X, Schmitz FJ, Govindan M, et al. 1995. Enzyme inhibitors New and known polybrominated phenols and diphenyl ethers from four Indo-Pacific Dysidea sponges. 

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