Dysidea sponges

Fu, X. and Schmitz, F. J. (1996). New brominated diphenyl ether from an unidentified species of Dysidea sponge. 13C NMR data for some brominated diphenyl ethers. J. Nat. Prod. 59, 1102-1103. 

Fu X, Schmitz FJ, Govindan M, et al. 1995. Enzyme inhibitors New and known polybrominated phenols and diphenyl ethers from four Indo-Pacific Dysidea sponges. 

From another Dysidea sponge species, Dysidea avara, the sesquiterpenes avarol, Fig. (9) and avarone, Fig. (10), which show a wide variety of biological activities, were first isolated. Both compounds are potent antileukemic agents in vitro and in vivo. They were determined to be neither direct mutagens nor premutagens, and they displayed antimutagenic activity... 

Another cultivation of Microcystis aeruginosa NIVA Cya 43 yielded the new cyanopeptolin 954 (1004), which is a chymotrypsin inhibitor (1041). The newly isolated chlorodysinosin A (1005), from a Dysidea sponge, has been synthesized and its structure confirmed (1042). 

A study of South Pacific marine invertebrates has revealed the new 1891 in the sponge Dysidea herbacea (1760). The new 1892 was isolated from Sagaminop-teron bilealbum molluscs feeding on the sponge Dysidea herbacea from Guam waters (1761). Four samples of Dysidea sponges from the Indo-Pacific yielded the... 

Fu X, Schmitz FJ (1996) New Brominated Diphenyl Ether from an Unidentified Species of Dysidea Sponge. 13C NMR Data for Some Brominated Diphenyl Ethers. J Nat Prod 59 1102... 

Fu, X., Schmitz, F.J., Govmdan, M., Abbas, SA., Hanson, K.M., Horton, P.A., Crews, P., Laney, M., and Schaizman, R.C. (1995) Enzyme inhibitors new and known polybrominated phenols and diphenylethers from four Indo-Padfic Dysidea sponges. J. Nat. Prod., 58,1384-1391. 

McPhail, K.L., Rivett, D.E.A., Lack, D.E., and Davies-Coleman, M.T. (2000) The structure and synthesis of tsitsikammafuran a new furanosesquiterpene from a South African Dysidea sponge. Tetrahedron, 56, 9391-9396. 

Dysidazirine 130 was isolated by Ireland in 1988 from a Fijian sample of the marine sponge Dysidea fragilis [194] as the major lipophilic component of the sponge and was shown to possess cytotoxic activity against L1210 cells, as well as... 

The first compound is an antibiotic isolated from Streptomyces aureus [20], while the second compound is a cytotoxic antibiotic isolated from Dysidea fragilis, a marine sponge [21]. A logical approach to the synthesis of azirines would be an elimination reaction of a suitably M-substituted aziridine. Thus, AT-chlorination of aziridine-2-carboxylic esters was carried out using ferf-butyl hypochlorite (Scheme 8). 

A novel natural product has been isolated from the Micronesian sponge Dysidea herbacea. This material is the zwitterionic pyrroloimidazopyridine 293 and is claimed to be the first example of a simple peptide with an N,N-aminal linkage <2004JOC1180>. 

Marine sponge - Dysidea sp. Dysamides - chiorinated naturai products 14, 26, 55... 

Becerro MA, Starmer JA, PaulVJ, Chemical defenses of cryptic and aposematic gastropterid molluscs feeding on their host sponge dysidea gtznuXosz., Journal of Chemical Ecology 52 (7) l491—1500, 2006. 

The indole 22 was previously isolated from the sponge Dysidea etheria [110] and has now been obtained from the Antarctic ice bacterium ARK 13-2-437. The lipid phase of Hel45 delivered additionally N-(2-hydroxyethyl)-ll-octadecen-amide and the new natural products 17-methyl-16-octadecenoic acid [95] and indole-3-carboxylic acid thiomethyl ester (23). 

More recently, the sesquiterpene A -isonakafuran-9-hydroperoxide (76) (P2j, O— O = 1.458 A, H—O—O—C = 63.3°, Figure 30) has been isolated from the dichlorometh-ane/methanol extract of the marine sponge Dysidea sp. nov . The peroxide is inhibitory to the marine fungus Trichophyton mentagrophytes and to murine leukemia cells. In view... 

Capon, R.J. Faulkna, D.J. (1985) Habasterol, an ichthyotoxic 9,11-secostaol from the sponge Dysidea herbacea. J. Org. Chem., 50,4771-3. 

Dunlop, R. W. Kazlauskas, R. March, G. Murphy, P.T. Wells, R. J. (1982) New fiirano-sesquiterpenes from the sponge Dysidea herbacea. Aust. J. Chem., 35,95-103. 

Flowers, A.E. Garson, M.J. Webb, R.I. Dumdei, E.J. Charan, R.D. (1998) Cellular origin of chlorinated diketopiperazines in the dictyoceratid sponge Dysidea herbacea (Keller). Cell Tissue Res., 292, 597-607. 

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