Uterine bleeding, dysfunctional

Since both PAs and SPRMs induce amenorrhea, they may be indicated in the treatment of this disorder. A single study has been reported in abstract form showing encouraging results with asoprisnil [99]. 

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Anovulatory bleeding, also referred to as dysfunctional uterine bleeding, is secondary to the effects of unopposed estrogen and does not include bleeding owing to an anatomic lesion of the uterus. 

Stenchever MA, Droegemueller W, Herbst AL, Mishell DR. Abnormal uterine bleeding Ovulatory and anovulatory dysfunctional uterine bleeding, management of acute and chronic excessive bleeding. In Stenchever MA, ed. Comprehensive Gynecology. 4th ed. St. Louis Mosby 2001 1079-1097. 

Dysfunctional uterine bleeding may occur during perimenopause. 

Progesterone Hormone produced naturally by corpus luteum, adrenals and placenta. Serum half-life is only a few minutes Dysfunctional uterine bleeding. Sustaining pregnancy in threatening abortion... 

High-dose monophasic preparations are indicated for the management of dysfunctional uterine bleedings and when persistent breakthrough bleedings occur with low-dose oral contraceptives. The monophasic combinations are taken in a fixed dose combination once daily over 21 or 22 days, followed by an interval of 7 or 6 days. 

Other clinical uses of estrogens and progestins include the treatment of dysfunctional uterine bleeding, dysmenorrhea, endometriosis, and rarely, metastatic prostate cancer. 

It is indicated as contraceptive, in hormone replacement therapy, primary and secondary amenorrhoea, dysfunctional uterine bleeding, endometriosis, postponement of menstruation, premenstrual syndrome, uterine hypoplasia, threatened or habitual abortion and premenstrual tension. It is also useful in endometrial carcinoma. 

It is used in dysfunctional uterine bleeding, secondary amenorrhoea and endometriosis. 

It is indicated in dysfunctional uterine bleeding, amenorrhoea, dysmenorrhoea, hypo and hypermenorrhoea, delay of menstrual period, oligo and polymenorrhoea, benign breast disease, endometriosis, metrorrhagia and endometrial carcinoma. 

Other clinical uses for the gonadal suppression provided by continuous GnRH agonist treatment include advanced breast and ovarian cancer thinning of the endometrial lining in preparation for an endometrial ablation procedure in women with dysfunctional uterine bleeding and treatment of amenorrhea and infertility in women with polycystic ovary disease. 

Various types of anemia, malnutrition, hypotension, dysfunctional uterine bleeding, infertility, thrombocytopenia, heavy blood loss after a surgical operation or delivery of a baby, mental disorders. 

Hickey M, Dwarte D, Fraser IS. Superficial endometrial vascular fragility in Norplant users and in women with ovulatory dysfunctional uterine bleeding. Hum Reprod 2000 15(7) 1509-14. 

Generic Name Hydroxyprogesterone Trade Name(s) Hylutin, Prodrox, others Primary Indication(s) Amenorrhea, dysfunctional uterine bleeding... 

Medroxyprogesterone Cycrin, Provera, others Secondary amenorrhea, dysfunctional uterine bleeding, breast or endometrial carcinoma... 

Endometriosis, Breast Cancer, and Dysfunctional Uterine Bleeding... 

Halbert DR. Menstrual delay and dysfunctional uterine bleeding associated with antiprostaglandin therapy for dysmenorrhea. J Reprod Med 1983 28(9) 592-4. 

Perimenopause Dysfunctional uterine bleeding owing to anovulatory cycles (other gynecologic disorders should be excluded)... 

Abnormalities of the endocrine system are also seen (M41). Pregnancy is rare in women whose serum creatinine exceeds 3 mg% and often ends in spontaneous abortion. Amenorrhea and dysfunctional uterine bleeding are common in women on hemodialysis. Ovarian production of estrogen and progestrone is decreased, leading to an increase in follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The secretion of FSH and LH increases after the administration of... 

The PA mifepristone also delays or inhibits ovulation, which may produce amenorrhea [48, 49]. Amenorrhea may be a consequence of an effect at the level of the ovary, pituitary or hypothalamus. The SPRM asoprisnil, in contrast, is not so effective in inhibiting ovulation [50]. The amenorrhea consequent to PAs and SPRMs occurs with levels of estradiol in the range of the early follicular phase of the menstrual cycle [48-50]. As a result ofthe antiproliferative effect and the amenorrhea, PAs and SPRMs have been advocated in the treatment of uterine myoma, endometriosis and dysfunctional uterine bleeding. 

Asoprisnil (J867) TAP Pharmaceuticals (USA) Schering (Germany) myomas, endometriosis, dysfunctional uterine bleeding... 

Org 33628, Org 31710 Organon (Netherlands) treatment of dysfunctional uterine bleeding during progestin-only contraception... 

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