Endometrial ablation

Other clinical uses for the gonadal suppression provided by continuous GnRH agonist treatment include advanced breast and ovarian cancer thinning of the endometrial lining in preparation for an endometrial ablation procedure in women with dysfunctional uterine bleeding and treatment of amenorrhea and infertility in women with polycystic ovary disease. 

Following pharmacokinetic studies of aminolevulinic acid-induced Protoporphyrin IX (PpIX) as photosensitizer in human endometrium [37], morphological and functional effects of photodynamic endometrial ablations in humans suffering dysfunctional uterine bleeding were evaluated at our clinic. 

In the functional study, a total of 10 sessions for photodynamic endometrial ablation were performed. One postmenopausal (PI) and five premenopausal patients (P2-P5) were treated. Malignancy was ruled out by prior diagnostic hysteroscopy... 

J. Donnez, R. Polet, P.E. Mathieu, E. Konwitz, M. Nisolle, F. Casanas-Roux (1996). Endometrial laser interstitial hyperthermy a potential modality for endometrial ablation. Obstetrics Gynecol., 87(3), 459-464. 

N.C. Sharp, N. Cronin, I. Feldberg, M. Evans, D. Hodgson, S. Ellis (1995). Microwaves for menorrhagia a new fast technique for endometrial ablation. Lancet, 346,1003-1004. 

G.A. Vilos, E.C. Vilos, L. Pendley (1996). Endometrial ablation with a thermal balloon for the treatment of menorrhagia. J. Am. Assoc. Gynecol. Laparosc., 3(3), 383-387. 

M. Baggish, M. Paraiso, E.M. Breznock, S. Griffey (1995). A computer-controlled, continuously circulating, hot irrigating system for endometrial ablation. Am. J. Obstet. Gynecol., 173, 1842-1848. 

P. Wyss, M. Fehr, H. Van-den-Bergh, U. Haller (1998). Feasibility of photodynamic endometrial ablation without anesthesia. Int. J. Gynaecol. Obstet., 60(3), 287-288. 

P. Wyss (2000). Photodynamic endometrial ablation Morphological and functional results. In P. Wyss, Y. Tadir, B. Tromberg, U. Haller (Eds), Photomedicine in Gynecology and Reproduction. Karger Verlag, 2000. 

P. Wyss, R. Caduff, Y. Tadir, A. Degen, G. Wagnieres, V. Schwarz, U. Haller, M. Fehr (2003). Photodynamic endometrial ablation Morphological study. Lasers Surg. Med., 32(4), 305-309. 

Traditionallysymptomaticfibroidshavebeen treated either surgically or medically. Surgical treatments include hysterectomy, myomectomy (either hy open procedure, laparoscopically or hysteroscopically), myolysis or endometrial ablation. 

Endometrial ablation is a permanent and invasive therapeutic option which relieves excessive menstrual bleeding in 62%-79% of cases [175]. Thermoablation of the endometrium is performed using a balloon or roller ball technique and a hysteroscopic access. The success of endometrial ablation in the presence of fibroids is small since not the entire endometrium is accessible in women with multiple leiomyomas because of enlargement and deformity of the uterine cavity. 

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