Multifunctional drug carriers

Numerous chromatographic studies have also been carried out to investigate possible applications of CyDs as multifunctional drug carriers, discussed in more detail in Chapters 14 and 15. For example the retention of psoralen derivatives was investigated on a C-18 column with HP-) -cyclodextrin as mobile phase additive [62]. Assuming 1 1 stoichiometry, in a 52 48 (v/v) methanol water mixture and temperature —5 °C, the corresponding stability constants were 30, 75, and 40 for the complexes of 8-methoxypsoralen, 5-methoxypsoralen and trimethylpsoralen with HP-yS-CyD, respectively. 

Design and synthesis of multifunctional drug carriers based on luminescent rattle-type mesoporous silica microspheres with a thermosensitive hydrogel as a controlled switch. Adv,... 

Furthermore, polymantanes have the potential to be utilized in the rational design of multifunctional drug systems and drug carriers. In host-guest chemistry, there is plenty of room for working with diamondoids. 

Bernkop-Schniirch, A. and Walker, G. Multifunctional matrices for oral peptide delivery. Crit. Rev. Ther. Drug Carrier Syst. 2001 18, 5, 459-501. 

Lastly, multifunctional scaffolds are also attractive platforms for treating bone diseases. As discussed before, 2-D and 3-D scaffolds can serve both as a cell/tis-sue support and a drug carrier. Recent research has attempted to extend the scope of scaffold functions and fabricate smart scaffolds that can simultaneously incorporate disease sensing, diagnosis, imaging, and treatment. To realize this, numerous nanomaterials can be used to fulfill these functions and immobilized into/onto scaffolds. For... 

Wischke C, Lendlein A (2010) Shape-memory polymers as drug carriers—a multifunctional system. Pharm Res 27(4) 527-529... 

Wischke, C. and A. Lendlein (2010), Shape-memory polymers as drug carriers-a multifunctional system. Pharmaceutical Research, 27(4) pp. 527-529. 

Multifunctional carrier matrices offer various advantages for oral drug delivery. Their application for oral drug delivery is described in Chapter 8. Generally, such carriers can be used either to protect the drug from enzymatic degradation via steric hindrance or to directly inhibit enzymes. Multifunctional polymers that can inhibit GI proteolytic enzymes per se are polyacrylates and modifications thereof as well as polymer-inhibitor... 

Among the several drug delivery systems, liposomes - phospholipid nanosized vesicles with a bilayered membrane structure - have drawn a lot of interest as advanced and versatile pharmaceutical carriers for both low and high molecular weight pharmaceuticals. At present, liposomal formulations span multiple areas, from clinical application of the liposomal drugs to the development of various multifunctional liposomal systems to be used in therapy and diagnostics. This chapter provides a brief overview of various liposomal products currently under development at experimental and preclinical level. 

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