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Microbiological sources, drugs from

Clearly, the felicitous combination of technical factors which facilitated the initial burst of microbial metabolite drug discoveries no longer operates with the same effect. This has led to a judgment on the part of some that no important new antibacterial drugs or drug classes will be derived directly from microbiological sources in the future. [Pg.48]

That structural variation of congeners can spell the difference between drugs of little or no clinical utility and drugs of wide applicability can also be seen by comparing the properties of various members of antibiotic classes isolated solely from microbiological sources. Some of these cases are summarized in Table VIII. [Pg.74]

A massive phytochemical survey by the U.S. Department of Agriculture [610] has identified a number of useful sources of L-dopa, the most promising being cultivated velvet beans. However, the microbiological hydroxylation of A-formyl-L-tyrosine esters [436] can be duplicated chemically in excellent yield by the use of benzoyl peroxide in chloroform [611]. Reports state that L-dopa from Japanese sources is superior to that from the U.S.A. [612]. Suitability of patients for L-dopa therapy can be assessed by determination of homovanillic acid and 5-hydroxyindole-3-acetic acid levels before and after treatment with probenecid [613, 614]. This drug reduces the outflow of brain monoamine metabolites into the blood and provides an index of the degree of... [Pg.254]

Although bacterial endotoxins are of microbiological origin, they are not lost with loss of viability. Of the sterilization processes commonly used in the manufacture of sterile parenteral dosage forms (see above), only dry heat is capable of destroying bacterial endotoxins in a reasonable time frame. There is therefore no practical way of removing bacterial endotoxins from finished drug products thus, they must be controlled at source. [Pg.2293]


See other pages where Microbiological sources, drugs from is mentioned: [Pg.41]    [Pg.41]    [Pg.41]    [Pg.41]    [Pg.48]    [Pg.201]    [Pg.831]    [Pg.27]    [Pg.99]    [Pg.1080]    [Pg.256]    [Pg.439]    [Pg.467]    [Pg.67]    [Pg.39]    [Pg.325]    [Pg.579]    [Pg.116]    [Pg.137]    [Pg.550]    [Pg.552]    [Pg.1585]    [Pg.2286]    [Pg.180]    [Pg.155]    [Pg.73]    [Pg.34]   
See also in sourсe #XX -- [ Pg.33 ]




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