Drugs factors

Selection of presumptive therapy considering every infected site Host factors Drug factors... 

Dialysis Dialysis is indicated in a minority of severe overdose cases. Drug factors that alter dialysis effectiveness include volume of distribution, drug... 

Anticoagulants and Other Drugs/ Factors Causing Maternal Bleeding... 

It is important to note that the elimination half-life is a derived term, and any process that changes k will change the half-life of the drug. Factors that may affect pharmacokinetic parameters are discussed elsewhere, but in this example may include disease states, changes in urinary pH, changes in plasma protein binding, and coadministration of other drugs. 

Bickers DR. Environmental and drug factors in hepatic porphyria. Acta Dermatol Venereol Suppl (Stockh) 1982 100 29-41. 

Pharmacokinetics (PK) can be a major source of variability in the dose response relationship. It manifests itself in interindividual differences in the plasma concentration-time profile of a drug. Factors which lead to variability in the ADME parameters are therefore of importance in understanding overall variability in PK. 

Drug factors Quality Pure, known degree of (harmful) adulterants... 

When counselling whether or not to treat, and with which drug, factors such as the severity and type of seizure disorder also need to be taken in to accoimt since control of major seizures is of fundamental importance. 

Use of formulation techniques can improve the bioavailability and/or minimize the toxicity and side effects of drugs. Factors to consider include those that impact on solubility and dissolution rates, chemical and enzymatic stability, and absorption capability. 

Dmgs administered by the rectal route in suppositories are placed in intimate contact with the rectal mucosa, which behaves as a normal lipoidal barrier. The pH in the rectal cavity lies between 7.2 and 7.4, but the rectal fluids have little buffering capacity. As with topical medication, the formulation of the suppository can have marked effects on the activity of the drug. Factors such as retention of the suppository for a sufficient duration of time in the rectal cavity also influence the outcome of therapy the size and shape of the suppository and its melting point may also determine bioavailability. 

One point about alcohol s acute effects is that alcohol generally acts on the body as a depressant, and its acute effects are proportional to the magnitude of the BAG. Simply put, as the BAG increases, acute effects increase in number and intensity. However, how humans experience some degree of intoxication and behave under different doses of alcohol may be modified by psychological and situational factors as well as alcohol dose and tolerance to this drug. For some behaviors these nondrug factors may be even more powerful determinants of alcohol s acute effects than drug factors. 

Arthritis and degenerative joint disease treatment of Asthma treatment of Autonomic receptors Benzodiazepines uses of Beta-adrenergic-receptor-blocking agents Bioavailabihty of drugs factors influencing Botuhnum toxin A uses of... 

Both processes, however, are influenced by the physicochemical and structural characteristics of the drug. Factors influencing plasma membrane partitioning are solute size, lipophilicity, hydrogenbonding potential, and charge characteristics, whereas the diffusion coefficient is dependent on size or total molecular surface area. In general, a non-PSA favors partitioning. 

Nakashima T, Taurog A, Riesco G. Mechanism of action of thioureylene antithyroid drugs factors affecting intrathyroidal metabolism of propylthiouracil and methimazole in rats. Endocrinology 1978 103 2187-2197. 

---