Drugs concepts

Testa, B., Crivori, P., Reist, M., Carrupt, P. A. The influence of lipophilicity on the pharmacokinetic behavior of drugs concepts and examples. Perspect. Drug Discov. Des. 2000, 79,179-211. 

Stephenson, V.C., Heydingb, R.A. and Weaver, D.F. (2005) The promiscuous drug concept with applications to Alzheimer s disease. FEES letters, 579 (6), 1338-1342. 

The soft drug concept was introduced in 1976 [24] and reiterated in 1980 [30-32], Since then, five distinct types have been identified [21, 25, 27-29, 33] (1) soft analogues, (2) soft drugs based on the inactive metabolite approach, (3)... 

This is an extension of the polymeric drug concept in which the drug can be conjugated to a polymeric matrix and... 

The C-6 side-chain functions of antibiotics have been used to develop the pro-dual-drug concept <2002BMC3489>. Compounds 64 and 65, combining clavulanic acid and amoxicillin, show a notable activity against /3-lactamase-producing microorganisms. 

Various other acyloxyalkyl esters of penicillins and cephalosporins were patented, which gave the inventors positions in the penicillin/cephalosporin market. In short, the pro-drug concept affords many opportunities to impart desirable properties to APIs. 

The crating drug concept is evaluated by revisiting a recent redesign of imatinib [15], the anticancer drug adopted to treat chronic myeloid leukemia (CML) [3, 4], As previously described in Chaps. 7 and 8, this inhibitor was originally designed to... 

Stephenson, V. C., Heyding, R. A., Weaver, D. F. The promiscuous drug concept with appUcations to Alzheimer s disease. FEBS Lett. 2005, 579,1338-1342. 

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