Concept of drug accumulation in the body

As mentioned in the introduction to this chapter, the administration of a drug in a multiple dose 

Calculation of drug accumulation from the average plasma concentration 

During any dosing interval, the average plasma concentration of a drug may be defined as  

The inverse ratio, (Cp)ss/(Cp)i, may be defined as an accumulation factor (R) hence. 

Integrating Equation 11.5 from t=0 to t=r, following substituting of dose/V for (Cp)o, yields  

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