The Soft Drug Concept

The soft drug concept was introduced in 1976 [24] and reiterated in 1980 [30-32], Since then, five distinct types have been identified [21, 25, 27-29, 33] (1) soft analogues, (2) soft drugs based on the inactive metabolite approach, (3)... 

Bodor, who pioneered the concept and coined the term, has defined soft drugs as ... 

A typical example is succinylcholine (suxamethonium, 7.62), although the discovery of this agent predates by decades the concept of soft drugs. In most individuals, this curarimimetic agent is very rapidly hydrolyzed to choline by plasma cholinesterase with a tm value of ca. 4 min [76] [134],... 

As a powerful methodology to assemble various components into soft supramolecular organizations, the LbL assembly method shows continuous progresses in the fields of drug delivery under the supramolecular concept (Fig. 2.2.5). The LbL method has excellent versatility for the assembly of various kinds of substances [13]. This method covers a wide range of available materials including proteins, nucleic acids, saccharides, virus particles micelles, vesicles, LB films, and other lipid membranes as well as conventional polyelectrolytes, conductive polymers, inorganic nanomaterials, nanocarbons, and dye... 

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